Multiplex mapping of chromatin accessibility and DNA methylation within targeted single molecules identifies epigenetic heterogeneity in neural stem cells and glioblastoma

Human tumors are comprised of heterogeneous cell populations that display diverse molecular and phenotypic features. To examine the extent to which epigenetic differences contribute to intratumoral cellular heterogeneity, we have developed a high-throughput method, termed MAPit-patch. The method use...

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Detalles Bibliográficos
Autores principales: Nabilsi, Nancy H., Deleyrolle, Loic P., Darst, Russell P., Riva, Alberto, Reynolds, Brent A., Kladde, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912423/
https://www.ncbi.nlm.nih.gov/pubmed/24105770
http://dx.doi.org/10.1101/gr.161737.113

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