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Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1
The unique functional properties and molecular identity of neuronal cell populations rely on cell type–specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly ex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912522/ https://www.ncbi.nlm.nih.gov/pubmed/24469635 http://dx.doi.org/10.1083/jcb.201310136 |
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author | Iijima, Takatoshi Iijima, Yoko Witte, Harald Scheiffele, Peter |
author_facet | Iijima, Takatoshi Iijima, Yoko Witte, Harald Scheiffele, Peter |
author_sort | Iijima, Takatoshi |
collection | PubMed |
description | The unique functional properties and molecular identity of neuronal cell populations rely on cell type–specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain–containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type–specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo. |
format | Online Article Text |
id | pubmed-3912522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39125222014-08-03 Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 Iijima, Takatoshi Iijima, Yoko Witte, Harald Scheiffele, Peter J Cell Biol Research Articles The unique functional properties and molecular identity of neuronal cell populations rely on cell type–specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain–containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type–specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo. The Rockefeller University Press 2014-02-03 /pmc/articles/PMC3912522/ /pubmed/24469635 http://dx.doi.org/10.1083/jcb.201310136 Text en © 2014 Iijima et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Iijima, Takatoshi Iijima, Yoko Witte, Harald Scheiffele, Peter Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title | Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title_full | Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title_fullStr | Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title_full_unstemmed | Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title_short | Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1 |
title_sort | neuronal cell type–specific alternative splicing is regulated by the kh domain protein slm1 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912522/ https://www.ncbi.nlm.nih.gov/pubmed/24469635 http://dx.doi.org/10.1083/jcb.201310136 |
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