Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives()

A chemoenzymatic strategy for the synthesis of enantiomerically pure novel alkaloids (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinolines is presented. The key steps are the biocatalytic stereoselective reductive amination of substituted 1-phenylpropan-2-one derivatives to yield chiral amin...

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Detalles Bibliográficos
Autores principales: Orden, Alejandro A., Schrittwieser, Joerg H., Resch, Verena, Mutti, Francesco G., Kroutil, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912595/
https://www.ncbi.nlm.nih.gov/pubmed/24503964
http://dx.doi.org/10.1016/j.tetasy.2013.05.003

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