A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazein, Alexander, Watterson, Steven, Hsieh, Wei-Yuan, Griffiths, William J., Ghazal, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912678/
https://www.ncbi.nlm.nih.gov/pubmed/23583456
http://dx.doi.org/10.1016/j.bcp.2013.03.021
_version_ 1782302121357475840
author Mazein, Alexander
Watterson, Steven
Hsieh, Wei-Yuan
Griffiths, William J.
Ghazal, Peter
author_facet Mazein, Alexander
Watterson, Steven
Hsieh, Wei-Yuan
Griffiths, William J.
Ghazal, Peter
author_sort Mazein, Alexander
collection PubMed
description Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.
format Online
Article
Text
id pubmed-3912678
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-39126782014-02-04 A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway Mazein, Alexander Watterson, Steven Hsieh, Wei-Yuan Griffiths, William J. Ghazal, Peter Biochem Pharmacol Article Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format. Elsevier Science 2013-07-01 /pmc/articles/PMC3912678/ /pubmed/23583456 http://dx.doi.org/10.1016/j.bcp.2013.03.021 Text en © 2013 Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Mazein, Alexander
Watterson, Steven
Hsieh, Wei-Yuan
Griffiths, William J.
Ghazal, Peter
A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_full A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_fullStr A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_full_unstemmed A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_short A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
title_sort comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912678/
https://www.ncbi.nlm.nih.gov/pubmed/23583456
http://dx.doi.org/10.1016/j.bcp.2013.03.021
work_keys_str_mv AT mazeinalexander acomprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT wattersonsteven acomprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT hsiehweiyuan acomprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT griffithswilliamj acomprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT ghazalpeter acomprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT mazeinalexander comprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT wattersonsteven comprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT hsiehweiyuan comprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT griffithswilliamj comprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway
AT ghazalpeter comprehensivemachinereadableviewofthemammaliancholesterolbiosynthesispathway

Ejemplares similares