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Squash cytology of primary central nervous system lymphoma in an immunocompetent patient

The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in st...

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Autores principales: Myageri, Aneel, Vandana, U.G., Melkundi, Sateesh, Patil, Preetam B., Kulkarni, Padmaja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912772/
https://www.ncbi.nlm.nih.gov/pubmed/24551005
http://dx.doi.org/10.4103/1793-5482.125673
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author Myageri, Aneel
Vandana, U.G.
Melkundi, Sateesh
Patil, Preetam B.
Kulkarni, Padmaja
author_facet Myageri, Aneel
Vandana, U.G.
Melkundi, Sateesh
Patil, Preetam B.
Kulkarni, Padmaja
author_sort Myageri, Aneel
collection PubMed
description The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections. Cytologic appreciation of tumor cells as lymphoid origin in squash smears negated the other possibilities. The immunocytochemistry on squash smear and immunohistochemistry on paraffin sections confirmed the diagnosis of diffuse large B cell lymphoma of non-germinal center B cell phenotype
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spelling pubmed-39127722014-02-18 Squash cytology of primary central nervous system lymphoma in an immunocompetent patient Myageri, Aneel Vandana, U.G. Melkundi, Sateesh Patil, Preetam B. Kulkarni, Padmaja Asian J Neurosurg Case Report The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections. Cytologic appreciation of tumor cells as lymphoid origin in squash smears negated the other possibilities. The immunocytochemistry on squash smear and immunohistochemistry on paraffin sections confirmed the diagnosis of diffuse large B cell lymphoma of non-germinal center B cell phenotype Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3912772/ /pubmed/24551005 http://dx.doi.org/10.4103/1793-5482.125673 Text en Copyright: © Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Myageri, Aneel
Vandana, U.G.
Melkundi, Sateesh
Patil, Preetam B.
Kulkarni, Padmaja
Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title_full Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title_fullStr Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title_full_unstemmed Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title_short Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
title_sort squash cytology of primary central nervous system lymphoma in an immunocompetent patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912772/
https://www.ncbi.nlm.nih.gov/pubmed/24551005
http://dx.doi.org/10.4103/1793-5482.125673
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