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Squash cytology of primary central nervous system lymphoma in an immunocompetent patient
The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912772/ https://www.ncbi.nlm.nih.gov/pubmed/24551005 http://dx.doi.org/10.4103/1793-5482.125673 |
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author | Myageri, Aneel Vandana, U.G. Melkundi, Sateesh Patil, Preetam B. Kulkarni, Padmaja |
author_facet | Myageri, Aneel Vandana, U.G. Melkundi, Sateesh Patil, Preetam B. Kulkarni, Padmaja |
author_sort | Myageri, Aneel |
collection | PubMed |
description | The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections. Cytologic appreciation of tumor cells as lymphoid origin in squash smears negated the other possibilities. The immunocytochemistry on squash smear and immunohistochemistry on paraffin sections confirmed the diagnosis of diffuse large B cell lymphoma of non-germinal center B cell phenotype |
format | Online Article Text |
id | pubmed-3912772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39127722014-02-18 Squash cytology of primary central nervous system lymphoma in an immunocompetent patient Myageri, Aneel Vandana, U.G. Melkundi, Sateesh Patil, Preetam B. Kulkarni, Padmaja Asian J Neurosurg Case Report The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections. Cytologic appreciation of tumor cells as lymphoid origin in squash smears negated the other possibilities. The immunocytochemistry on squash smear and immunohistochemistry on paraffin sections confirmed the diagnosis of diffuse large B cell lymphoma of non-germinal center B cell phenotype Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3912772/ /pubmed/24551005 http://dx.doi.org/10.4103/1793-5482.125673 Text en Copyright: © Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Myageri, Aneel Vandana, U.G. Melkundi, Sateesh Patil, Preetam B. Kulkarni, Padmaja Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title | Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title_full | Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title_fullStr | Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title_full_unstemmed | Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title_short | Squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
title_sort | squash cytology of primary central nervous system lymphoma in an immunocompetent patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912772/ https://www.ncbi.nlm.nih.gov/pubmed/24551005 http://dx.doi.org/10.4103/1793-5482.125673 |
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