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Effect of ovarian sex hormones on non-steroidal anti-inflammatory drug-induced gastric lesions in female rats
OBJECTIVE: The objective of the following study is to investigate the effect of ovarian sex hormones on gastric ulcer in female rats. MATERIALS AND METHODS: Female rats were treated daily with estrogen (0.05 and 0.1 mg/kg), progesterone (2.0 and 5.0 mg/kg), combined estrogen (0.05 mg/kg) and progest...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912794/ https://www.ncbi.nlm.nih.gov/pubmed/24550596 http://dx.doi.org/10.4103/0253-7613.125191 |
Sumario: | OBJECTIVE: The objective of the following study is to investigate the effect of ovarian sex hormones on gastric ulcer in female rats. MATERIALS AND METHODS: Female rats were treated daily with estrogen (0.05 and 0.1 mg/kg), progesterone (2.0 and 5.0 mg/kg), combined estrogen (0.05 mg/kg) and progesterone (2.0 mg/kg), ranitidine (30 mg/kg) or vehicle for 7 days. Ulcers were induced with aspirin on 7(th) day. Four hours later, animals were sacrificed and stomach were removed for macroscopic and biochemical examination. RESULTS: Estrogen in 0.05 and 0.1 doses showed 32% and 18% of ulcer inhibition, respectively, progesterone 09% and 14% inhibition in 2.0 and 5.0 mg/kg doses, respectively, whereas combined estrogen and progesterone showed 23% and ranitidine showed 60% inhibition. However, the inhibition attained and the stomach malondialdehyde and glutathione levels in sex hormone treated groups were not statistically significant when compared to control group. CONCLUSION: At the tested doses, these ovarian sex hormones neither worsen nor protect against aspirin-induced gastric lesions in female rats. |
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