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Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance
Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through E...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912880/ https://www.ncbi.nlm.nih.gov/pubmed/24511540 http://dx.doi.org/10.1155/2014/627126 |
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author | Zhou, Ling Lu, Guoyuan Shen, Lei Wang, Linfeng Wang, Mingjun |
author_facet | Zhou, Ling Lu, Guoyuan Shen, Lei Wang, Linfeng Wang, Mingjun |
author_sort | Zhou, Ling |
collection | PubMed |
description | Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through ELISA measurement. And their interrelationships were also systematically analyzed. The SLE patients were then divided into active SLE group and inactive SLE group according to the SLEDAI score. The results show that serum levels of PlGF, bFGF, and VEGF in all SLE group and active SLE group were higher than those in normal controls. Serum levels of PlGF and bFGF in inactive SLE group were higher than those in normal controls. The level of PlGF was positively correlated with VEGF in SLE patients and positive correlation is also shown in bFGF with VEGF. The levels of PlGF and VEGF in SLE patients were positively correlated with both ESR and SLEDAI score. Thus a tentative conclusion can be drawn that the serum levels of the angiogenic factors, for example, PlGF, bFGF, and VEGF, may be relevant in the pathogenesis of SLE, and the concentrations of PlGF and VEGF seem to be the markers of SLE activity. |
format | Online Article Text |
id | pubmed-3912880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39128802014-02-09 Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance Zhou, Ling Lu, Guoyuan Shen, Lei Wang, Linfeng Wang, Mingjun Biomed Res Int Research Article Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through ELISA measurement. And their interrelationships were also systematically analyzed. The SLE patients were then divided into active SLE group and inactive SLE group according to the SLEDAI score. The results show that serum levels of PlGF, bFGF, and VEGF in all SLE group and active SLE group were higher than those in normal controls. Serum levels of PlGF and bFGF in inactive SLE group were higher than those in normal controls. The level of PlGF was positively correlated with VEGF in SLE patients and positive correlation is also shown in bFGF with VEGF. The levels of PlGF and VEGF in SLE patients were positively correlated with both ESR and SLEDAI score. Thus a tentative conclusion can be drawn that the serum levels of the angiogenic factors, for example, PlGF, bFGF, and VEGF, may be relevant in the pathogenesis of SLE, and the concentrations of PlGF and VEGF seem to be the markers of SLE activity. Hindawi Publishing Corporation 2014 2014-01-06 /pmc/articles/PMC3912880/ /pubmed/24511540 http://dx.doi.org/10.1155/2014/627126 Text en Copyright © 2014 Ling Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhou, Ling Lu, Guoyuan Shen, Lei Wang, Linfeng Wang, Mingjun Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title | Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title_full | Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title_fullStr | Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title_full_unstemmed | Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title_short | Serum Levels of Three Angiogenic Factors in Systemic Lupus Erythematosus and Their Clinical Significance |
title_sort | serum levels of three angiogenic factors in systemic lupus erythematosus and their clinical significance |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912880/ https://www.ncbi.nlm.nih.gov/pubmed/24511540 http://dx.doi.org/10.1155/2014/627126 |
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