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Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study

Heat shock protein 72 (Hsp72) exhibits a protective role during times of increased risk of pathogenic challenge and/or tissue damage. The aim of the study was to ascertain Hsp72 protective effect differences between animal and human studies in sepsis using a hypothetical “comparative study” model. F...

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Autores principales: Briassoulis, George, Briassouli, Efrossini, Fitrolaki, Diana-Michaela, Plati, Ioanna, Apostolou, Kleovoulos, Tavladaki, Theonymfi, Spanaki, Anna-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912989/
https://www.ncbi.nlm.nih.gov/pubmed/24524071
http://dx.doi.org/10.1155/2014/101023
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author Briassoulis, George
Briassouli, Efrossini
Fitrolaki, Diana-Michaela
Plati, Ioanna
Apostolou, Kleovoulos
Tavladaki, Theonymfi
Spanaki, Anna-Maria
author_facet Briassoulis, George
Briassouli, Efrossini
Fitrolaki, Diana-Michaela
Plati, Ioanna
Apostolou, Kleovoulos
Tavladaki, Theonymfi
Spanaki, Anna-Maria
author_sort Briassoulis, George
collection PubMed
description Heat shock protein 72 (Hsp72) exhibits a protective role during times of increased risk of pathogenic challenge and/or tissue damage. The aim of the study was to ascertain Hsp72 protective effect differences between animal and human studies in sepsis using a hypothetical “comparative study” model. Forty-one in vivo (56.1%), in vitro (17.1%), or combined (26.8%) animal and 14 in vivo (2) or in vitro (12) human Hsp72 studies (P < 0.0001) were enrolled in the analysis. Of the 14 human studies, 50% showed a protective Hsp72 effect compared to 95.8% protection shown in septic animal studies (P < 0.0001). Only human studies reported Hsp72-associated mortality (21.4%) or infection (7.1%) or reported results (14.3%) to be nonprotective (P < 0.001). In animal models, any Hsp72 induction method tried increased intracellular Hsp72 (100%), compared to 57.1% of human studies (P < 0.02), reduced proinflammatory cytokines (28/29), and enhanced survival (18/18). Animal studies show a clear Hsp72 protective effect in sepsis. Human studies are inconclusive, showing either protection or a possible relation to mortality and infections. This might be due to the fact that using evermore purified target cell populations in animal models, a lot of clinical information regarding the net response that occurs in sepsis is missing.
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spelling pubmed-39129892014-02-12 Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study Briassoulis, George Briassouli, Efrossini Fitrolaki, Diana-Michaela Plati, Ioanna Apostolou, Kleovoulos Tavladaki, Theonymfi Spanaki, Anna-Maria Biomed Res Int Review Article Heat shock protein 72 (Hsp72) exhibits a protective role during times of increased risk of pathogenic challenge and/or tissue damage. The aim of the study was to ascertain Hsp72 protective effect differences between animal and human studies in sepsis using a hypothetical “comparative study” model. Forty-one in vivo (56.1%), in vitro (17.1%), or combined (26.8%) animal and 14 in vivo (2) or in vitro (12) human Hsp72 studies (P < 0.0001) were enrolled in the analysis. Of the 14 human studies, 50% showed a protective Hsp72 effect compared to 95.8% protection shown in septic animal studies (P < 0.0001). Only human studies reported Hsp72-associated mortality (21.4%) or infection (7.1%) or reported results (14.3%) to be nonprotective (P < 0.001). In animal models, any Hsp72 induction method tried increased intracellular Hsp72 (100%), compared to 57.1% of human studies (P < 0.02), reduced proinflammatory cytokines (28/29), and enhanced survival (18/18). Animal studies show a clear Hsp72 protective effect in sepsis. Human studies are inconclusive, showing either protection or a possible relation to mortality and infections. This might be due to the fact that using evermore purified target cell populations in animal models, a lot of clinical information regarding the net response that occurs in sepsis is missing. Hindawi Publishing Corporation 2014 2014-01-12 /pmc/articles/PMC3912989/ /pubmed/24524071 http://dx.doi.org/10.1155/2014/101023 Text en Copyright © 2014 George Briassoulis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Briassoulis, George
Briassouli, Efrossini
Fitrolaki, Diana-Michaela
Plati, Ioanna
Apostolou, Kleovoulos
Tavladaki, Theonymfi
Spanaki, Anna-Maria
Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title_full Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title_fullStr Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title_full_unstemmed Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title_short Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
title_sort heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies—a hypothetical “comparative” study
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912989/
https://www.ncbi.nlm.nih.gov/pubmed/24524071
http://dx.doi.org/10.1155/2014/101023
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