Ginseng Total Saponins Reverse Corticosterone-Induced Changes in Depression-Like Behavior and Hippocampal Plasticity-Related Proteins by Interfering with GSK-3β-CREB Signaling Pathway

This study aimed to explore the antidepressant mechanisms of ginseng total saponins (GTS) in the corticosterone-induced mouse depression model. In Experiment 1, GTS (50, 25, and 12.5 mg kg(−1) d(−1), intragastrically) were given for 3 weeks. In Experiment 2, the same doses of GTS were administrated...

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Detalles Bibliográficos
Autores principales: Chen, Lin, Dai, Jianguo, Wang, Zhongli, Zhang, Huiyu, Huang, Yufang, Zhao, Yunan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913067/
https://www.ncbi.nlm.nih.gov/pubmed/24523822
http://dx.doi.org/10.1155/2014/506735

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