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Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes
As women get older their oocytes become susceptible to chromosome mis-segregation. This generates aneuploid embryos, leading to increased infertility and birth defects. Here we examined the provenance of aneuploidy by tracking chromosomes and their kinetochores in oocytes from young and aged mice. C...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Company of Biologists
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913075/ https://www.ncbi.nlm.nih.gov/pubmed/24346700 http://dx.doi.org/10.1242/dev.100206 |