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Signaling pathways controlling skeletal muscle mass
The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance bet...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare USA, Inc.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913083/ https://www.ncbi.nlm.nih.gov/pubmed/24237131 http://dx.doi.org/10.3109/10409238.2013.857291 |
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author | Egerman, Marc A. Glass, David J. |
author_facet | Egerman, Marc A. Glass, David J. |
author_sort | Egerman, Marc A. |
collection | PubMed |
description | The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed “atrophy”, is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle. |
format | Online Article Text |
id | pubmed-3913083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Informa Healthcare USA, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39130832014-02-10 Signaling pathways controlling skeletal muscle mass Egerman, Marc A. Glass, David J. Crit Rev Biochem Mol Biol Review Article The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed “atrophy”, is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle. Informa Healthcare USA, Inc. 2014-01 2013-11-18 /pmc/articles/PMC3913083/ /pubmed/24237131 http://dx.doi.org/10.3109/10409238.2013.857291 Text en © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. |
spellingShingle | Review Article Egerman, Marc A. Glass, David J. Signaling pathways controlling skeletal muscle mass |
title | Signaling pathways controlling skeletal muscle mass |
title_full | Signaling pathways controlling skeletal muscle mass |
title_fullStr | Signaling pathways controlling skeletal muscle mass |
title_full_unstemmed | Signaling pathways controlling skeletal muscle mass |
title_short | Signaling pathways controlling skeletal muscle mass |
title_sort | signaling pathways controlling skeletal muscle mass |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913083/ https://www.ncbi.nlm.nih.gov/pubmed/24237131 http://dx.doi.org/10.3109/10409238.2013.857291 |
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