Cargando…

Signaling pathways controlling skeletal muscle mass

The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance bet...

Descripción completa

Detalles Bibliográficos
Autores principales: Egerman, Marc A., Glass, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare USA, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913083/
https://www.ncbi.nlm.nih.gov/pubmed/24237131
http://dx.doi.org/10.3109/10409238.2013.857291
_version_ 1782302173183344640
author Egerman, Marc A.
Glass, David J.
author_facet Egerman, Marc A.
Glass, David J.
author_sort Egerman, Marc A.
collection PubMed
description The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed “atrophy”, is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle.
format Online
Article
Text
id pubmed-3913083
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Informa Healthcare USA, Inc.
record_format MEDLINE/PubMed
spelling pubmed-39130832014-02-10 Signaling pathways controlling skeletal muscle mass Egerman, Marc A. Glass, David J. Crit Rev Biochem Mol Biol Review Article The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed “atrophy”, is a diagnostic feature of cachexia seen in settings of cancer, heart disease, chronic obstructive pulmonary disease, kidney disease, and burns. Cachexia increases the likelihood of death from these already serious diseases. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce differentiation and post-injury regeneration, which are also essential for the maintenance of skeletal muscle mass. In this review, we summarize and discuss the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle. Informa Healthcare USA, Inc. 2014-01 2013-11-18 /pmc/articles/PMC3913083/ /pubmed/24237131 http://dx.doi.org/10.3109/10409238.2013.857291 Text en © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Review Article
Egerman, Marc A.
Glass, David J.
Signaling pathways controlling skeletal muscle mass
title Signaling pathways controlling skeletal muscle mass
title_full Signaling pathways controlling skeletal muscle mass
title_fullStr Signaling pathways controlling skeletal muscle mass
title_full_unstemmed Signaling pathways controlling skeletal muscle mass
title_short Signaling pathways controlling skeletal muscle mass
title_sort signaling pathways controlling skeletal muscle mass
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913083/
https://www.ncbi.nlm.nih.gov/pubmed/24237131
http://dx.doi.org/10.3109/10409238.2013.857291
work_keys_str_mv AT egermanmarca signalingpathwayscontrollingskeletalmusclemass
AT glassdavidj signalingpathwayscontrollingskeletalmusclemass