Cargando…
Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls
The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive s...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913386/ https://www.ncbi.nlm.nih.gov/pubmed/24523984 http://dx.doi.org/10.1155/2014/179384 |
_version_ | 1782302213595463680 |
---|---|
author | Tanvir, Imrana Riaz, Sabiha Hussain, Afshan Mehboob, Riffat Shams, M. Usman Khan, Haseeb Ahmad |
author_facet | Tanvir, Imrana Riaz, Sabiha Hussain, Afshan Mehboob, Riffat Shams, M. Usman Khan, Haseeb Ahmad |
author_sort | Tanvir, Imrana |
collection | PubMed |
description | The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive study carried out on 52 specimens of endometrial tumors received in Fatima Memorial Hospital, Lahore, Pakistan, during three years (2010–2012). Patients were divided into 5 age groups: <40, 41–50, 51–60, 61–70, and >70 yrs. Tissues were fixed in 10% formalin and processed and stained with haematoxylin-eosin. Stained slides were examined to determine the histological types by WHO classification, and immunohistochemistry for WT1, p53, ER/PR, and MIB1 was done in cases where morphology alone was not helpful in making a confirmed diagnosis. 80% of specimens were of endometrioid adenocarcinomas, 11% of serous tumors, 4% of clear cell carcinoma, and 4% of squamous cell carcinomas involving both cervix and endometrium. Most of the patients (28.84%) with endometrial carcinomas fall in the age range of 51–60 yrs. Endometrioid adenocarcinoma is the most common type of epithelial endometrial malignancies. Morphology is the keystone in the evaluation of these tumors, but immunohistochemistry can also be helpful in establishing the correct diagnosis. |
format | Online Article Text |
id | pubmed-3913386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39133862014-02-12 Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls Tanvir, Imrana Riaz, Sabiha Hussain, Afshan Mehboob, Riffat Shams, M. Usman Khan, Haseeb Ahmad Patholog Res Int Research Article The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive study carried out on 52 specimens of endometrial tumors received in Fatima Memorial Hospital, Lahore, Pakistan, during three years (2010–2012). Patients were divided into 5 age groups: <40, 41–50, 51–60, 61–70, and >70 yrs. Tissues were fixed in 10% formalin and processed and stained with haematoxylin-eosin. Stained slides were examined to determine the histological types by WHO classification, and immunohistochemistry for WT1, p53, ER/PR, and MIB1 was done in cases where morphology alone was not helpful in making a confirmed diagnosis. 80% of specimens were of endometrioid adenocarcinomas, 11% of serous tumors, 4% of clear cell carcinoma, and 4% of squamous cell carcinomas involving both cervix and endometrium. Most of the patients (28.84%) with endometrial carcinomas fall in the age range of 51–60 yrs. Endometrioid adenocarcinoma is the most common type of epithelial endometrial malignancies. Morphology is the keystone in the evaluation of these tumors, but immunohistochemistry can also be helpful in establishing the correct diagnosis. Hindawi Publishing Corporation 2014 2014-01-06 /pmc/articles/PMC3913386/ /pubmed/24523984 http://dx.doi.org/10.1155/2014/179384 Text en Copyright © 2014 Imrana Tanvir et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tanvir, Imrana Riaz, Sabiha Hussain, Afshan Mehboob, Riffat Shams, M. Usman Khan, Haseeb Ahmad Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title | Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title_full | Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title_fullStr | Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title_full_unstemmed | Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title_short | Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls |
title_sort | hospital-based study of epithelial malignancies of endometrial cancer frequency in lahore, pakistan, and common diagnostic pitfalls |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913386/ https://www.ncbi.nlm.nih.gov/pubmed/24523984 http://dx.doi.org/10.1155/2014/179384 |
work_keys_str_mv | AT tanvirimrana hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls AT riazsabiha hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls AT hussainafshan hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls AT mehboobriffat hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls AT shamsmusman hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls AT khanhaseebahmad hospitalbasedstudyofepithelialmalignanciesofendometrialcancerfrequencyinlahorepakistanandcommondiagnosticpitfalls |