Design, Synthesis, and In Vitro Kinetics Study of Atenolol Prodrugs for the Use in Aqueous Formulations

Based on DFT, MP2, and the density functional from Truhlar group (hybrid GGA: MPW1k) calculations for an acid-catalyzed hydrolysis of nine Kirby's N-alkylmaleamic acids and two atenolol prodrugs were designed. The calculations demonstrated that the amide bond cleavage is due to intramolecular n...

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Detalles Bibliográficos
Autores principales: Karaman, Rafik, Qtait, Alaa, Dajani, Khulod Khayyat, Abu Lafi, Saleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913492/
https://www.ncbi.nlm.nih.gov/pubmed/24526887
http://dx.doi.org/10.1155/2014/248651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913492/
https://www.ncbi.nlm.nih.gov/pubmed/24526887
http://dx.doi.org/10.1155/2014/248651

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