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An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi

We present a customized high content (image-based) and high throughput screening algorithm for the quantification of Trypanosoma cruzi infection in host cells. Based solely on DNA staining and single-channel images, the algorithm precisely segments and identifies the nuclei and cytoplasm of mammalia...

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Detalles Bibliográficos
Autores principales:	Moon, Seunghyun, Siqueira-Neto, Jair L., Moraes, Carolina Borsoi, Yang, Gyongseon, Kang, Myungjoo, Freitas-Junior, Lucio H., Hansen, Michael A. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913590/ https://www.ncbi.nlm.nih.gov/pubmed/24503652 http://dx.doi.org/10.1371/journal.pone.0087188

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