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Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via...
Autores principales: | Cohen, Jarish N., Tewalt, Eric F., Rouhani, Sherin J., Buonomo, Erica L., Bruce, Amber N., Xu, Xiaojiang, Bekiranov, Stefan, Fu, Yang-Xin, Engelhard, Victor H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913631/ https://www.ncbi.nlm.nih.gov/pubmed/24503860 http://dx.doi.org/10.1371/journal.pone.0087740 |
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