Cargando…
EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3
The epidermal growth factor receptor (EGFR) supports the escape of malignant cells from immunosurveillance by inhibiting the activation of signal transducer and activator of transcription 1 (STAT1) while promoting that of STAT3. We have recently demonstrated that protein tyrosine phosphatase, non-re...
Autores principales: | Concha-Benavente, Fernando, Srivastava, Raghvendra M, Ferrone, Soldano, Ferris, Robert L |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913673/ https://www.ncbi.nlm.nih.gov/pubmed/24501692 http://dx.doi.org/10.4161/onci.27215 |
Ejemplares similares
-
Reversing EGFR Mediated Immunoescape by Targeted Monoclonal Antibody Therapy
por: Concha-Benavente, Fernando, et al.
Publicado: (2017) -
STAT1 contributes to HLA class I upregulation and CTL reactivity after anti-EGFR mAb cetuximab therapy in head and neck cancer patients
por: Srivastava, Raghvendra M, et al.
Publicado: (2013) -
STAT3 activation: A key factor in tumor immunoescape
por: Rébé, Cédric, et al.
Publicado: (2013) -
Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition
por: McQuade, Jennifer L, et al.
Publicado: (2015) -
Novel function of STAT1 in breast cancer
por: Zhang, Ming
Publicado: (2013)