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Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/ https://www.ncbi.nlm.nih.gov/pubmed/24505442 http://dx.doi.org/10.1371/journal.pone.0088232 |
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author | Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan |
author_facet | Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan |
author_sort | Chen, Jie |
collection | PubMed |
description | PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver. RESULTS: Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76±8.21%/s, phase = 26.93±15.67°, and CVR = 1.53±0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery = 39.62±27.99%/s, phase = 55.66±22.10°, and CVR = 2.18±0.80%/mmHg, respectively). Rate of recovery (r = −0.698, p<0.001), phase (r = −0.738, p<0.001)) and CVR (r = −0.690, p<0.001) were all significantly correlated with the degree of stenosis. CONCLUSION: Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree. |
format | Online Article Text |
id | pubmed-3913771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39137712014-02-06 Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan PLoS One Research Article PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver. RESULTS: Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery = 17.76±8.21%/s, phase = 26.93±15.67°, and CVR = 1.53±0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery = 39.62±27.99%/s, phase = 55.66±22.10°, and CVR = 2.18±0.80%/mmHg, respectively). Rate of recovery (r = −0.698, p<0.001), phase (r = −0.738, p<0.001)) and CVR (r = −0.690, p<0.001) were all significantly correlated with the degree of stenosis. CONCLUSION: Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree. Public Library of Science 2014-02-04 /pmc/articles/PMC3913771/ /pubmed/24505442 http://dx.doi.org/10.1371/journal.pone.0088232 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title | Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title_full | Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title_fullStr | Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title_full_unstemmed | Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title_short | Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis |
title_sort | impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/ https://www.ncbi.nlm.nih.gov/pubmed/24505442 http://dx.doi.org/10.1371/journal.pone.0088232 |
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