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Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis

PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cer...

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Autores principales: Chen, Jie, Liu, Jia, Xu, Wei-Hai, Xu, Ren, Hou, Bo, Cui, Li-Ying, Gao, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/
https://www.ncbi.nlm.nih.gov/pubmed/24505442
http://dx.doi.org/10.1371/journal.pone.0088232
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author Chen, Jie
Liu, Jia
Xu, Wei-Hai
Xu, Ren
Hou, Bo
Cui, Li-Ying
Gao, Shan
author_facet Chen, Jie
Liu, Jia
Xu, Wei-Hai
Xu, Ren
Hou, Bo
Cui, Li-Ying
Gao, Shan
author_sort Chen, Jie
collection PubMed
description PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver. RESULTS: Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery  = 17.76±8.21%/s, phase  = 26.93±15.67°, and CVR  = 1.53±0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery  = 39.62±27.99%/s, phase  = 55.66±22.10°, and CVR  = 2.18±0.80%/mmHg, respectively). Rate of recovery (r = −0.698, p<0.001), phase (r = −0.738, p<0.001)) and CVR (r = −0.690, p<0.001) were all significantly correlated with the degree of stenosis. CONCLUSION: Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree.
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spelling pubmed-39137712014-02-06 Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis Chen, Jie Liu, Jia Xu, Wei-Hai Xu, Ren Hou, Bo Cui, Li-Ying Gao, Shan PLoS One Research Article PURPOSE: We sought to investigate the capacity of cerebral autoregulation and cerebrovascular reactivity (CVR) in patients with middle cerebral artery (MCA) stenosis. METHODS: Twenty-one patients with MCA stenosis diagnosed by magnetic resonance angiography and 15 healthy controls were enrolled. Cerebral autoregulation was assessed by autoregulatory parameters (rate of recovery/phase/gain) derived from transfer function from spontaneous oscillations of cerebral blood flow velocity and blood pressure. CVR was tested by a rebreathing maneuver. RESULTS: Rate of recovery, phase and CVR estimated from moderate MCA stenosis (rate of recovery  = 17.76±8.21%/s, phase  = 26.93±15.67°, and CVR  = 1.53±0.84%/mmHg, respectively) were significantly different (p<0.05) from controls (rate of recovery  = 39.62±27.99%/s, phase  = 55.66±22.10°, and CVR  = 2.18±0.80%/mmHg, respectively). Rate of recovery (r = −0.698, p<0.001), phase (r = −0.738, p<0.001)) and CVR (r = −0.690, p<0.001) were all significantly correlated with the degree of stenosis. CONCLUSION: Cerebral autoregulation and CVR were impaired in patients with ≥ 50% MCA stenosis. The measures of both hemodynamic properties were inversely correlated with the stenotic degree. Public Library of Science 2014-02-04 /pmc/articles/PMC3913771/ /pubmed/24505442 http://dx.doi.org/10.1371/journal.pone.0088232 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chen, Jie
Liu, Jia
Xu, Wei-Hai
Xu, Ren
Hou, Bo
Cui, Li-Ying
Gao, Shan
Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title_full Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title_fullStr Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title_full_unstemmed Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title_short Impaired Dynamic Cerebral Autoregulation and Cerebrovascular Reactivity in Middle Cerebral Artery Stenosis
title_sort impaired dynamic cerebral autoregulation and cerebrovascular reactivity in middle cerebral artery stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913771/
https://www.ncbi.nlm.nih.gov/pubmed/24505442
http://dx.doi.org/10.1371/journal.pone.0088232
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