Drug-Induced Trafficking of P-Glycoprotein in Human Brain Capillary Endothelial Cells as Demonstrated by Exposure to Mitomycin C

P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), restricting the penetration of various compounds. In other tissues, trafficking of Pgp from subcellular stores to the cell surface has been demonstrated and may constitute a rapid way of the cell to resp...

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Detalles Bibliográficos
Autores principales: Noack, Andreas, Noack, Sandra, Hoffmann, Andrea, Maalouf, Katia, Buettner, Manuela, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette, Alms, Dana, Römermann, Kerstin, Naim, Hassan Y., Löscher, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913777/
https://www.ncbi.nlm.nih.gov/pubmed/24505408
http://dx.doi.org/10.1371/journal.pone.0088154

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