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The role of tumor-associated macrophages in tumor vascularization

Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and k...

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Autores principales: Guo, Chunqing, Buranych, Annicole, Sarkar, Devanand, Fisher, Paul B, Wang, Xiang-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913793/
https://www.ncbi.nlm.nih.gov/pubmed/24314323
http://dx.doi.org/10.1186/2045-824X-5-20
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author Guo, Chunqing
Buranych, Annicole
Sarkar, Devanand
Fisher, Paul B
Wang, Xiang-Yang
author_facet Guo, Chunqing
Buranych, Annicole
Sarkar, Devanand
Fisher, Paul B
Wang, Xiang-Yang
author_sort Guo, Chunqing
collection PubMed
description Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that TAMs play a critical role in promoting the formation of an abnormal tumor vascular network and subsequent tumor progression and invasion. Clinical and experimental evidence has shown that high levels of infiltrating TAMs are associated with poor patient prognosis and tumor resistance to therapies. In addition to stimulating angiogenesis during tumor growth, TAMs enhance tumor revascularization in response to cytotoxic therapy (e.g., radiotherapy), thereby causing cancer relapse. In this review, we highlight the emerging data related to the phenotype and polarization of TAMs in the tumor microenvironment, as well as the underlying mechanisms of macrophage function in the regulation of the angiogenic switch and tumor vascularization. Additionally, we discuss the potential of targeting pro-angiogenic TAMs, or reprograming TAMs toward a tumoricidal and angiostatic phenotype, to promote normalization of the tumor vasculature to enhance the outcome of cancer therapies.
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spelling pubmed-39137932014-02-06 The role of tumor-associated macrophages in tumor vascularization Guo, Chunqing Buranych, Annicole Sarkar, Devanand Fisher, Paul B Wang, Xiang-Yang Vasc Cell Review Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that TAMs play a critical role in promoting the formation of an abnormal tumor vascular network and subsequent tumor progression and invasion. Clinical and experimental evidence has shown that high levels of infiltrating TAMs are associated with poor patient prognosis and tumor resistance to therapies. In addition to stimulating angiogenesis during tumor growth, TAMs enhance tumor revascularization in response to cytotoxic therapy (e.g., radiotherapy), thereby causing cancer relapse. In this review, we highlight the emerging data related to the phenotype and polarization of TAMs in the tumor microenvironment, as well as the underlying mechanisms of macrophage function in the regulation of the angiogenic switch and tumor vascularization. Additionally, we discuss the potential of targeting pro-angiogenic TAMs, or reprograming TAMs toward a tumoricidal and angiostatic phenotype, to promote normalization of the tumor vasculature to enhance the outcome of cancer therapies. BioMed Central 2013-12-06 /pmc/articles/PMC3913793/ /pubmed/24314323 http://dx.doi.org/10.1186/2045-824X-5-20 Text en Copyright © 2013 Guo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Guo, Chunqing
Buranych, Annicole
Sarkar, Devanand
Fisher, Paul B
Wang, Xiang-Yang
The role of tumor-associated macrophages in tumor vascularization
title The role of tumor-associated macrophages in tumor vascularization
title_full The role of tumor-associated macrophages in tumor vascularization
title_fullStr The role of tumor-associated macrophages in tumor vascularization
title_full_unstemmed The role of tumor-associated macrophages in tumor vascularization
title_short The role of tumor-associated macrophages in tumor vascularization
title_sort role of tumor-associated macrophages in tumor vascularization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913793/
https://www.ncbi.nlm.nih.gov/pubmed/24314323
http://dx.doi.org/10.1186/2045-824X-5-20
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