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Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()

BACKGROUND: The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions. METHODS: Functional magnetic resonance imaging (fM...

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Autores principales: Fonville, Leon, Giampietro, Vincent, Surguladze, Simon, Williams, Steven, Tchanturia, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913832/
https://www.ncbi.nlm.nih.gov/pubmed/24501698
http://dx.doi.org/10.1016/j.nicl.2013.12.002
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author Fonville, Leon
Giampietro, Vincent
Surguladze, Simon
Williams, Steven
Tchanturia, Kate
author_facet Fonville, Leon
Giampietro, Vincent
Surguladze, Simon
Williams, Steven
Tchanturia, Kate
author_sort Fonville, Leon
collection PubMed
description BACKGROUND: The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions. METHODS: Functional magnetic resonance imaging (fMRI) was used alongside a FEPT, depicting neutral, mildly happy and happy faces, to examine the neural correlates of implicit emotion processing in AN. Participants were instructed to specify the gender of the faces. Levels of depression, anxiety, obsessive–compulsive symptoms and eating disorder behaviour were obtained and principal component analysis (PCA) was performed to acquire uncorrelated variables. RESULTS: fMRI analysis revealed a greater blood-oxygenation level dependent (BOLD) response in AN in the right fusiform gyrus to all facial expressions. This response showed a linear increase with the happiness of the facial expression and was found to be stronger in those not taking medication. PCA analysis revealed a single component indicating a greater level of general clinical symptoms. CONCLUSION: Neuroimaging findings would suggest that alterations in implicit emotion processing in AN occur during early perceptual processing of social signals and illustrate greater engagement on the FEPT. The lack of separate components using PCA suggests that the questionnaires used might not be suited as predictive measures.
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spelling pubmed-39138322014-02-05 Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa() Fonville, Leon Giampietro, Vincent Surguladze, Simon Williams, Steven Tchanturia, Kate Neuroimage Clin Regular Articles BACKGROUND: The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions. METHODS: Functional magnetic resonance imaging (fMRI) was used alongside a FEPT, depicting neutral, mildly happy and happy faces, to examine the neural correlates of implicit emotion processing in AN. Participants were instructed to specify the gender of the faces. Levels of depression, anxiety, obsessive–compulsive symptoms and eating disorder behaviour were obtained and principal component analysis (PCA) was performed to acquire uncorrelated variables. RESULTS: fMRI analysis revealed a greater blood-oxygenation level dependent (BOLD) response in AN in the right fusiform gyrus to all facial expressions. This response showed a linear increase with the happiness of the facial expression and was found to be stronger in those not taking medication. PCA analysis revealed a single component indicating a greater level of general clinical symptoms. CONCLUSION: Neuroimaging findings would suggest that alterations in implicit emotion processing in AN occur during early perceptual processing of social signals and illustrate greater engagement on the FEPT. The lack of separate components using PCA suggests that the questionnaires used might not be suited as predictive measures. Elsevier 2013-12-07 /pmc/articles/PMC3913832/ /pubmed/24501698 http://dx.doi.org/10.1016/j.nicl.2013.12.002 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-nd/3.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/3.0/) .
spellingShingle Regular Articles
Fonville, Leon
Giampietro, Vincent
Surguladze, Simon
Williams, Steven
Tchanturia, Kate
Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title_full Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title_fullStr Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title_full_unstemmed Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title_short Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
title_sort increased bold signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa()
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913832/
https://www.ncbi.nlm.nih.gov/pubmed/24501698
http://dx.doi.org/10.1016/j.nicl.2013.12.002
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