Limited geographic distribution of the novel cyclovirus CyCV-VN

A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infec...

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Detalles Bibliográficos
Autores principales: Tan, Le Van, de Jong, Menno D., Van Kinh, Nguyen, Trung, Nguyen Vu, Taylor, Walter, Wertheim, Heiman F. L., van der Ende, Arie, van der Hoek, Lia, Canuti, Marta, Crusat, Martin, Sona, Soeng, Uyen, Nguyen Hanh, Giri, Abhishek, Thi Thuy Chinh BKrong, Nguyen, Nghia, Ho Dang Trung, Farrar, Jeremy, Bryant, Juliet E., Hien, Tran Tinh, Van Vinh Chau, Nguyen, van Doorn, H. Rogier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913916/
https://www.ncbi.nlm.nih.gov/pubmed/24495921
http://dx.doi.org/10.1038/srep03967
Descripción
Sumario:A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.

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