Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT

The outcome of umbilical cord blood transplantation (UCBT) is compromised by low hematopoietic stem cell (HSC) doses leading to prolonged time to engraftment, delayed immunological reconstitution and late memory T-cell skewing. Exposure of UCB to dimethyl-prostaglandin E2 (dmPGE2) increases HSC in v...

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Detalles Bibliográficos
Autores principales: Li, L, Kim, H T, Nellore, A, Patsoukis, N, Petkova, V, McDonough, S, Politikos, I, Nikiforow, S, Soiffer, R, Antin, J H, Ballen, K, Cutler, C, Ritz, J, Boussiotis, V A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913944/
https://www.ncbi.nlm.nih.gov/pubmed/24442207
http://dx.doi.org/10.1038/bcj.2013.75

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