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Synthesis, in vitro aerobic and hypoxic cytotoxicity and radiosensitizing activity of novel metronidazole tethered 5-fluorouracil
BACKGROUND AND THE PURPOSE OF THE STUDY: Several 2, 4-dinitrophenyl and 2,4-dinitrophenylamine tethered 5-FU (5-fluorouracil) compared to their components have shown minimal or no cytotoxicity to HT-29 cell line under aerobic conditions but high cytotoxicity and radiosensitizing effects under hypoxi...
Autores principales: | Abdi, Khosrou, Khalaj, Ali, Ostad, Seyed Nasser, Lamei, Navid, Khoshayand, Mohammad Reza |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914007/ https://www.ncbi.nlm.nih.gov/pubmed/24359860 http://dx.doi.org/10.1186/2008-2231-21-76 |
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