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Synthesis, in vitro aerobic and hypoxic cytotoxicity and radiosensitizing activity of novel metronidazole tethered 5-fluorouracil

BACKGROUND AND THE PURPOSE OF THE STUDY: Several 2, 4-dinitrophenyl and 2,4-dinitrophenylamine tethered 5-FU (5-fluorouracil) compared to their components have shown minimal or no cytotoxicity to HT-29 cell line under aerobic conditions but high cytotoxicity and radiosensitizing effects under hypoxi...

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Detalles Bibliográficos
Autores principales:	Abdi, Khosrou, Khalaj, Ali, Ostad, Seyed Nasser, Lamei, Navid, Khoshayand, Mohammad Reza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914007/ https://www.ncbi.nlm.nih.gov/pubmed/24359860 http://dx.doi.org/10.1186/2008-2231-21-76

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