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Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats
The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914326/ https://www.ncbi.nlm.nih.gov/pubmed/24551855 http://dx.doi.org/10.1155/2014/907915 |
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author | Cure, Erkan Cumhur Cure, Medine Tumkaya, Levent Kalkan, Yildiray Aydin, Ibrahim Kirbas, Aynur Yilmaz, Arif Yuce, Suleyman Yücel, Ahmet Fikret |
author_facet | Cure, Erkan Cumhur Cure, Medine Tumkaya, Levent Kalkan, Yildiray Aydin, Ibrahim Kirbas, Aynur Yilmaz, Arif Yuce, Suleyman Yücel, Ahmet Fikret |
author_sort | Cure, Erkan |
collection | PubMed |
description | The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group containing 10 animals. Laparotomy without I/R injury was performed in the control group animals. Laparotomy in the I/R group was followed by two hours of infrarenal abdominal aortic cross ligation and then two hours of reperfusion. ADA (50 mg/kg) was administered intraperitoneally as a single dose, to the I/R+ADA group, five days before I/R. The tumor necrosis factor-alpha (TNF-α) (pg/mg protein) and nitric oxide (NO) (µmol/g protein) levels in the I/R group (430.8 ± 70.1, 8.0 ± 1.1, resp.) were significantly higher than those in the I/R+ADA group (338.0 ± 71.6, P = 0.006; 6.3 ± 1.2, P = 0.008) and the control group (345.5 ± 53.3, P = 0.008; 6.5 ± 1.5, P = 0.010, resp.). I/R causes severe histopathological injury to the liver tissue, but ADA leads to much less histopathological changes. ADA treatment significantly decreased the severity of liver I/R injury. ADA pretreatment may have protective effects on experimental liver injury. |
format | Online Article Text |
id | pubmed-3914326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39143262014-02-18 Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats Cure, Erkan Cumhur Cure, Medine Tumkaya, Levent Kalkan, Yildiray Aydin, Ibrahim Kirbas, Aynur Yilmaz, Arif Yuce, Suleyman Yücel, Ahmet Fikret Biomed Res Int Research Article The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group containing 10 animals. Laparotomy without I/R injury was performed in the control group animals. Laparotomy in the I/R group was followed by two hours of infrarenal abdominal aortic cross ligation and then two hours of reperfusion. ADA (50 mg/kg) was administered intraperitoneally as a single dose, to the I/R+ADA group, five days before I/R. The tumor necrosis factor-alpha (TNF-α) (pg/mg protein) and nitric oxide (NO) (µmol/g protein) levels in the I/R group (430.8 ± 70.1, 8.0 ± 1.1, resp.) were significantly higher than those in the I/R+ADA group (338.0 ± 71.6, P = 0.006; 6.3 ± 1.2, P = 0.008) and the control group (345.5 ± 53.3, P = 0.008; 6.5 ± 1.5, P = 0.010, resp.). I/R causes severe histopathological injury to the liver tissue, but ADA leads to much less histopathological changes. ADA treatment significantly decreased the severity of liver I/R injury. ADA pretreatment may have protective effects on experimental liver injury. Hindawi Publishing Corporation 2014 2014-01-16 /pmc/articles/PMC3914326/ /pubmed/24551855 http://dx.doi.org/10.1155/2014/907915 Text en Copyright © 2014 Erkan Cure et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cure, Erkan Cumhur Cure, Medine Tumkaya, Levent Kalkan, Yildiray Aydin, Ibrahim Kirbas, Aynur Yilmaz, Arif Yuce, Suleyman Yücel, Ahmet Fikret Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title | Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title_full | Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title_fullStr | Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title_full_unstemmed | Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title_short | Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats |
title_sort | adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914326/ https://www.ncbi.nlm.nih.gov/pubmed/24551855 http://dx.doi.org/10.1155/2014/907915 |
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