Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients

We have recently identified tumor necrosis factor receptor superfamily, member 9 (TNFRSF9, best known as CD137 or 4–1BB) as a biomarker of tumor-reactive T cells naturally occurring in cancer patients, and developed a rapid, accurate system to comprehensively isolate lymphocytes with tumor-rejecting...

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Detalles Bibliográficos
Autores principales: Ye, Qunrui, Song, De-Gang, Powell Jr, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914380/
https://www.ncbi.nlm.nih.gov/pubmed/24501691
http://dx.doi.org/10.4161/onci.27184
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author Ye, Qunrui
Song, De-Gang
Powell Jr, Daniel J
author_facet Ye, Qunrui
Song, De-Gang
Powell Jr, Daniel J
author_sort Ye, Qunrui
collection PubMed
description We have recently identified tumor necrosis factor receptor superfamily, member 9 (TNFRSF9, best known as CD137 or 4–1BB) as a biomarker of tumor-reactive T cells naturally occurring in cancer patients, and developed a rapid, accurate system to comprehensively isolate lymphocytes with tumor-rejecting properties from human biopsies. Our findings reveal a previously unappreciated role for CD137, a co-stimulatory TNFR family member, in the immunobiology of human cancer.
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spelling pubmed-39143802014-02-05 Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients Ye, Qunrui Song, De-Gang Powell Jr, Daniel J Oncoimmunology Author's View We have recently identified tumor necrosis factor receptor superfamily, member 9 (TNFRSF9, best known as CD137 or 4–1BB) as a biomarker of tumor-reactive T cells naturally occurring in cancer patients, and developed a rapid, accurate system to comprehensively isolate lymphocytes with tumor-rejecting properties from human biopsies. Our findings reveal a previously unappreciated role for CD137, a co-stimulatory TNFR family member, in the immunobiology of human cancer. Landes Bioscience 2013-12-01 2013-12-09 /pmc/articles/PMC3914380/ /pubmed/24501691 http://dx.doi.org/10.4161/onci.27184 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ye, Qunrui
Song, De-Gang
Powell Jr, Daniel J
Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title_full Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title_fullStr Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title_full_unstemmed Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title_short Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients
title_sort finding a needle in a haystack: activation-induced cd137 expression accurately identifies naturally occurring tumor-reactive t cells in cancer patients
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914380/
https://www.ncbi.nlm.nih.gov/pubmed/24501691
http://dx.doi.org/10.4161/onci.27184
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AT powelljrdanielj findinganeedleinahaystackactivationinducedcd137expressionaccuratelyidentifiesnaturallyoccurringtumorreactivetcellsincancerpatients

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