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MicroRNAs in Diabetic Kidney Disease

Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantat...

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Detalles Bibliográficos
Autores principales: Li, Rong, Chung, Arthur C. K., Yu, Xueqing, Lan, Hui Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914440/
https://www.ncbi.nlm.nih.gov/pubmed/24550986
http://dx.doi.org/10.1155/2014/593956
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author Li, Rong
Chung, Arthur C. K.
Yu, Xueqing
Lan, Hui Y.
author_facet Li, Rong
Chung, Arthur C. K.
Yu, Xueqing
Lan, Hui Y.
author_sort Li, Rong
collection PubMed
description Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. It is urgent to search for biomarkers for early diagnosis and effective therapy. The discovery of microRNAs had lead to a new era of post-transcriptional regulators of gene expression. Studies from cells, experimental animal models and patients under diabetic conditions demonstrate that expression patterns of microRNAs are altered during the progression of diabetic kidney disease. Functional studies indicate that the ability of microRNAs to bind 3′ untranslated region of messenger RNA not only shows their capability to regulate expression of target genes, but also their therapeutic potential to diabetic kidney disease. The presence of microRNAs in plasma, serum, and urine has been shown to be possible biomarkers in diabetic kidney disease. Therefore, identification of the pathogenic role of microRNAs possesses an important clinical impact in terms of prevention and treatment of progression in diabetic kidney disease because it allows us to design novel and specific therapies and diagnostic tools for diabetic kidney disease.
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spelling pubmed-39144402014-02-18 MicroRNAs in Diabetic Kidney Disease Li, Rong Chung, Arthur C. K. Yu, Xueqing Lan, Hui Y. Int J Endocrinol Review Article Rapid growth of diabetes and diabetic kidney disease exerts a great burden on society. Owing to the lack of effective treatments for diabetic kidney disease, treatment relies on drugs that either reduces its progression or involve renal replacement therapies, such as dialysis and kidney transplantation. It is urgent to search for biomarkers for early diagnosis and effective therapy. The discovery of microRNAs had lead to a new era of post-transcriptional regulators of gene expression. Studies from cells, experimental animal models and patients under diabetic conditions demonstrate that expression patterns of microRNAs are altered during the progression of diabetic kidney disease. Functional studies indicate that the ability of microRNAs to bind 3′ untranslated region of messenger RNA not only shows their capability to regulate expression of target genes, but also their therapeutic potential to diabetic kidney disease. The presence of microRNAs in plasma, serum, and urine has been shown to be possible biomarkers in diabetic kidney disease. Therefore, identification of the pathogenic role of microRNAs possesses an important clinical impact in terms of prevention and treatment of progression in diabetic kidney disease because it allows us to design novel and specific therapies and diagnostic tools for diabetic kidney disease. Hindawi Publishing Corporation 2014 2014-01-14 /pmc/articles/PMC3914440/ /pubmed/24550986 http://dx.doi.org/10.1155/2014/593956 Text en Copyright © 2014 Rong Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Rong
Chung, Arthur C. K.
Yu, Xueqing
Lan, Hui Y.
MicroRNAs in Diabetic Kidney Disease
title MicroRNAs in Diabetic Kidney Disease
title_full MicroRNAs in Diabetic Kidney Disease
title_fullStr MicroRNAs in Diabetic Kidney Disease
title_full_unstemmed MicroRNAs in Diabetic Kidney Disease
title_short MicroRNAs in Diabetic Kidney Disease
title_sort micrornas in diabetic kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914440/
https://www.ncbi.nlm.nih.gov/pubmed/24550986
http://dx.doi.org/10.1155/2014/593956
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