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Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914447/ https://www.ncbi.nlm.nih.gov/pubmed/24550697 http://dx.doi.org/10.1155/2014/260348 |
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author | Hudler, Petra Kocevar, Nina Komel, Radovan |
author_facet | Hudler, Petra Kocevar, Nina Komel, Radovan |
author_sort | Hudler, Petra |
collection | PubMed |
description | Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies. |
format | Online Article Text |
id | pubmed-3914447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39144472014-02-18 Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics Hudler, Petra Kocevar, Nina Komel, Radovan ScientificWorldJournal Review Article Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies. Hindawi Publishing Corporation 2014-01-14 /pmc/articles/PMC3914447/ /pubmed/24550697 http://dx.doi.org/10.1155/2014/260348 Text en Copyright © 2014 Petra Hudler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hudler, Petra Kocevar, Nina Komel, Radovan Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title_full | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title_fullStr | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title_full_unstemmed | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title_short | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
title_sort | proteomic approaches in biomarker discovery: new perspectives in cancer diagnostics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914447/ https://www.ncbi.nlm.nih.gov/pubmed/24550697 http://dx.doi.org/10.1155/2014/260348 |
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