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Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics

Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained...

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Detalles Bibliográficos
Autores principales: Hudler, Petra, Kocevar, Nina, Komel, Radovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914447/
https://www.ncbi.nlm.nih.gov/pubmed/24550697
http://dx.doi.org/10.1155/2014/260348
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author Hudler, Petra
Kocevar, Nina
Komel, Radovan
author_facet Hudler, Petra
Kocevar, Nina
Komel, Radovan
author_sort Hudler, Petra
collection PubMed
description Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies.
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spelling pubmed-39144472014-02-18 Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics Hudler, Petra Kocevar, Nina Komel, Radovan ScientificWorldJournal Review Article Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies. Hindawi Publishing Corporation 2014-01-14 /pmc/articles/PMC3914447/ /pubmed/24550697 http://dx.doi.org/10.1155/2014/260348 Text en Copyright © 2014 Petra Hudler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hudler, Petra
Kocevar, Nina
Komel, Radovan
Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title_full Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title_fullStr Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title_full_unstemmed Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title_short Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
title_sort proteomic approaches in biomarker discovery: new perspectives in cancer diagnostics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914447/
https://www.ncbi.nlm.nih.gov/pubmed/24550697
http://dx.doi.org/10.1155/2014/260348
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