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Updates in Reproduction Coming from the Endocannabinoid System
The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductiv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914453/ https://www.ncbi.nlm.nih.gov/pubmed/24550985 http://dx.doi.org/10.1155/2014/412354 |
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author | Meccariello, Rosaria Battista, Natalia Bradshaw, Heather B. Wang, Haibin |
author_facet | Meccariello, Rosaria Battista, Natalia Bradshaw, Heather B. Wang, Haibin |
author_sort | Meccariello, Rosaria |
collection | PubMed |
description | The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. This review provides an overview on ECS and reproduction and focuses on the insights in the regulation of endocannabinoid production by steroids, in the regulation of male reproductive activity, and in placentation and parturition. Taken all together, evidences emerge that the activity of the ECS is crucial for procreation and may represent a target for the therapeutic exploitation of infertility. |
format | Online Article Text |
id | pubmed-3914453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39144532014-02-18 Updates in Reproduction Coming from the Endocannabinoid System Meccariello, Rosaria Battista, Natalia Bradshaw, Heather B. Wang, Haibin Int J Endocrinol Review Article The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. This review provides an overview on ECS and reproduction and focuses on the insights in the regulation of endocannabinoid production by steroids, in the regulation of male reproductive activity, and in placentation and parturition. Taken all together, evidences emerge that the activity of the ECS is crucial for procreation and may represent a target for the therapeutic exploitation of infertility. Hindawi Publishing Corporation 2014 2014-01-16 /pmc/articles/PMC3914453/ /pubmed/24550985 http://dx.doi.org/10.1155/2014/412354 Text en Copyright © 2014 Rosaria Meccariello et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Meccariello, Rosaria Battista, Natalia Bradshaw, Heather B. Wang, Haibin Updates in Reproduction Coming from the Endocannabinoid System |
title | Updates in Reproduction Coming from the Endocannabinoid System |
title_full | Updates in Reproduction Coming from the Endocannabinoid System |
title_fullStr | Updates in Reproduction Coming from the Endocannabinoid System |
title_full_unstemmed | Updates in Reproduction Coming from the Endocannabinoid System |
title_short | Updates in Reproduction Coming from the Endocannabinoid System |
title_sort | updates in reproduction coming from the endocannabinoid system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914453/ https://www.ncbi.nlm.nih.gov/pubmed/24550985 http://dx.doi.org/10.1155/2014/412354 |
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