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An essential role for decorin in bladder cancer invasiveness
Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Here...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914526/ https://www.ncbi.nlm.nih.gov/pubmed/24142880 http://dx.doi.org/10.1002/emmm.201302655 |
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author | El Behi, Mohamed Krumeich, Sophie Lodillinsky, Catalina Kamoun, Aurélie Tibaldi, Lorenzo Sugano, Gaël De Reynies, Aurélien Chapeaublanc, Elodie Laplanche, Agnès Lebret, Thierry Allory, Yves Radvanyi, François Lantz, Olivier Eiján, Ana María Bernard-Pierrot, Isabelle Théry, Clotilde |
author_facet | El Behi, Mohamed Krumeich, Sophie Lodillinsky, Catalina Kamoun, Aurélie Tibaldi, Lorenzo Sugano, Gaël De Reynies, Aurélien Chapeaublanc, Elodie Laplanche, Agnès Lebret, Thierry Allory, Yves Radvanyi, François Lantz, Olivier Eiján, Ana María Bernard-Pierrot, Isabelle Théry, Clotilde |
author_sort | El Behi, Mohamed |
collection | PubMed |
description | Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours. |
format | Online Article Text |
id | pubmed-3914526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | John Wiley and Sons |
record_format | MEDLINE/PubMed |
spelling | pubmed-39145262014-02-10 An essential role for decorin in bladder cancer invasiveness El Behi, Mohamed Krumeich, Sophie Lodillinsky, Catalina Kamoun, Aurélie Tibaldi, Lorenzo Sugano, Gaël De Reynies, Aurélien Chapeaublanc, Elodie Laplanche, Agnès Lebret, Thierry Allory, Yves Radvanyi, François Lantz, Olivier Eiján, Ana María Bernard-Pierrot, Isabelle Théry, Clotilde EMBO Mol Med Research Articles Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we demonstrate that the adaptive immune system efficiently limits progression of MB49, whereas MB49-I has lost tumour antigens and is insensitive to adaptive immune responses. Furthermore, we unravel a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting angiogenesis and tumour cell invasiveness. Finally, we show that these results are relevant to muscle-invasive human bladder carcinomas, which overexpress decorin together with angiogenesis- and adhesion/migration-related genes, and that decorin overexpression in the human bladder carcinoma cell line TCCSUP is required for efficient invasiveness in vitro. We thus propose decorin as a new therapeutic target for these aggressive tumours. John Wiley and Sons 2013-12 2013-10-20 /pmc/articles/PMC3914526/ /pubmed/24142880 http://dx.doi.org/10.1002/emmm.201302655 Text en © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles El Behi, Mohamed Krumeich, Sophie Lodillinsky, Catalina Kamoun, Aurélie Tibaldi, Lorenzo Sugano, Gaël De Reynies, Aurélien Chapeaublanc, Elodie Laplanche, Agnès Lebret, Thierry Allory, Yves Radvanyi, François Lantz, Olivier Eiján, Ana María Bernard-Pierrot, Isabelle Théry, Clotilde An essential role for decorin in bladder cancer invasiveness |
title | An essential role for decorin in bladder cancer invasiveness |
title_full | An essential role for decorin in bladder cancer invasiveness |
title_fullStr | An essential role for decorin in bladder cancer invasiveness |
title_full_unstemmed | An essential role for decorin in bladder cancer invasiveness |
title_short | An essential role for decorin in bladder cancer invasiveness |
title_sort | essential role for decorin in bladder cancer invasiveness |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914526/ https://www.ncbi.nlm.nih.gov/pubmed/24142880 http://dx.doi.org/10.1002/emmm.201302655 |
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