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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, rece...

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Detalles Bibliográficos
Autores principales: Jones, Emma V., Bouvier, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914553/
https://www.ncbi.nlm.nih.gov/pubmed/24551460
http://dx.doi.org/10.1155/2014/321209
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author Jones, Emma V.
Bouvier, David S.
author_facet Jones, Emma V.
Bouvier, David S.
author_sort Jones, Emma V.
collection PubMed
description Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.
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spelling pubmed-39145532014-02-18 Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease Jones, Emma V. Bouvier, David S. Neural Plast Review Article Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases. Hindawi Publishing Corporation 2014 2014-01-16 /pmc/articles/PMC3914553/ /pubmed/24551460 http://dx.doi.org/10.1155/2014/321209 Text en Copyright © 2014 E. V. Jones and D. S. Bouvier. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jones, Emma V.
Bouvier, David S.
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title_full Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title_fullStr Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title_full_unstemmed Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title_short Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
title_sort astrocyte-secreted matricellular proteins in cns remodelling during development and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914553/
https://www.ncbi.nlm.nih.gov/pubmed/24551460
http://dx.doi.org/10.1155/2014/321209
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