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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, rece...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914553/ https://www.ncbi.nlm.nih.gov/pubmed/24551460 http://dx.doi.org/10.1155/2014/321209 |
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author | Jones, Emma V. Bouvier, David S. |
author_facet | Jones, Emma V. Bouvier, David S. |
author_sort | Jones, Emma V. |
collection | PubMed |
description | Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-3914553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39145532014-02-18 Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease Jones, Emma V. Bouvier, David S. Neural Plast Review Article Matricellular proteins are secreted, nonstructural proteins that regulate the extracellular matrix (ECM) and interactions between cells through modulation of growth factor signaling, cell adhesion, migration, and proliferation. Despite being well described in the context of nonneuronal tissues, recent studies have revealed that these molecules may also play instrumental roles in central nervous system (CNS) development and diseases. In this minireview, we discuss the matricellular protein families SPARC (secreted protein acidic and rich in cysteine), Hevin/SC1 (SPARC-like 1), TN-C (Tenascin C), TSP (Thrombospondin), and CCN (CYR61/CTGF/NOV), which are secreted by astrocytes during development. These proteins exhibit a reduced expression in adult CNS but are upregulated in reactive astrocytes following injury or disease, where they are well placed to modulate the repair processes such as tissue remodeling, axon regeneration, glial scar formation, angiogenesis, and rewiring of neural circuitry. Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases. Hindawi Publishing Corporation 2014 2014-01-16 /pmc/articles/PMC3914553/ /pubmed/24551460 http://dx.doi.org/10.1155/2014/321209 Text en Copyright © 2014 E. V. Jones and D. S. Bouvier. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jones, Emma V. Bouvier, David S. Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title_full | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title_fullStr | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title_full_unstemmed | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title_short | Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease |
title_sort | astrocyte-secreted matricellular proteins in cns remodelling during development and disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914553/ https://www.ncbi.nlm.nih.gov/pubmed/24551460 http://dx.doi.org/10.1155/2014/321209 |
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