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Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variab...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914592/ https://www.ncbi.nlm.nih.gov/pubmed/24527207 http://dx.doi.org/10.1155/2014/201657 |
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author | Ripellino, Paolo Fleetwood, Thomas Cantello, Roberto Comi, Cristoforo |
author_facet | Ripellino, Paolo Fleetwood, Thomas Cantello, Roberto Comi, Cristoforo |
author_sort | Ripellino, Paolo |
collection | PubMed |
description | Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variable degree of sensory dysfunction; disease evolution may also differ from patient to patient, since monophasic, progressive, and relapsing forms are reported. Underlying such clinical variability there is probably a broad spectrum of molecular dysfunctions that are and will be the target of therapeutic strategies. In this review we first explore the biological bases of current treatments and subsequently we focus on the practical management that must also take into account pharmacoeconomic issues. |
format | Online Article Text |
id | pubmed-3914592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39145922014-02-13 Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations Ripellino, Paolo Fleetwood, Thomas Cantello, Roberto Comi, Cristoforo Autoimmune Dis Review Article Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variable degree of sensory dysfunction; disease evolution may also differ from patient to patient, since monophasic, progressive, and relapsing forms are reported. Underlying such clinical variability there is probably a broad spectrum of molecular dysfunctions that are and will be the target of therapeutic strategies. In this review we first explore the biological bases of current treatments and subsequently we focus on the practical management that must also take into account pharmacoeconomic issues. Hindawi Publishing Corporation 2014 2014-01-14 /pmc/articles/PMC3914592/ /pubmed/24527207 http://dx.doi.org/10.1155/2014/201657 Text en Copyright © 2014 Paolo Ripellino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ripellino, Paolo Fleetwood, Thomas Cantello, Roberto Comi, Cristoforo Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title | Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title_full | Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title_fullStr | Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title_full_unstemmed | Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title_short | Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations |
title_sort | treatment of chronic inflammatory demyelinating polyneuropathy: from molecular bases to practical considerations |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914592/ https://www.ncbi.nlm.nih.gov/pubmed/24527207 http://dx.doi.org/10.1155/2014/201657 |
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