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Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variab...

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Detalles Bibliográficos
Autores principales: Ripellino, Paolo, Fleetwood, Thomas, Cantello, Roberto, Comi, Cristoforo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914592/
https://www.ncbi.nlm.nih.gov/pubmed/24527207
http://dx.doi.org/10.1155/2014/201657
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author Ripellino, Paolo
Fleetwood, Thomas
Cantello, Roberto
Comi, Cristoforo
author_facet Ripellino, Paolo
Fleetwood, Thomas
Cantello, Roberto
Comi, Cristoforo
author_sort Ripellino, Paolo
collection PubMed
description Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variable degree of sensory dysfunction; disease evolution may also differ from patient to patient, since monophasic, progressive, and relapsing forms are reported. Underlying such clinical variability there is probably a broad spectrum of molecular dysfunctions that are and will be the target of therapeutic strategies. In this review we first explore the biological bases of current treatments and subsequently we focus on the practical management that must also take into account pharmacoeconomic issues.
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spelling pubmed-39145922014-02-13 Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations Ripellino, Paolo Fleetwood, Thomas Cantello, Roberto Comi, Cristoforo Autoimmune Dis Review Article Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, in which both cellular and humoral immune responses are involved. The disease is clinically heterogeneous with some patients displaying pure motor form and others also showing a variable degree of sensory dysfunction; disease evolution may also differ from patient to patient, since monophasic, progressive, and relapsing forms are reported. Underlying such clinical variability there is probably a broad spectrum of molecular dysfunctions that are and will be the target of therapeutic strategies. In this review we first explore the biological bases of current treatments and subsequently we focus on the practical management that must also take into account pharmacoeconomic issues. Hindawi Publishing Corporation 2014 2014-01-14 /pmc/articles/PMC3914592/ /pubmed/24527207 http://dx.doi.org/10.1155/2014/201657 Text en Copyright © 2014 Paolo Ripellino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ripellino, Paolo
Fleetwood, Thomas
Cantello, Roberto
Comi, Cristoforo
Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title_full Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title_fullStr Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title_full_unstemmed Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title_short Treatment of Chronic Inflammatory Demyelinating Polyneuropathy: From Molecular Bases to Practical Considerations
title_sort treatment of chronic inflammatory demyelinating polyneuropathy: from molecular bases to practical considerations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914592/
https://www.ncbi.nlm.nih.gov/pubmed/24527207
http://dx.doi.org/10.1155/2014/201657
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