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Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin

The identification and validation of gene–gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of neonatal diabetes mellitus. Expression of the mutant preproinsulin (hINS(C96Y)) in the eye imagina...

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Detalles Bibliográficos
Autores principales:	He, Bin Z., Ludwig, Michael Z., Dickerson, Desiree A., Barse, Levi, Arun, Bharath, Vilhjálmsson, Bjarni J., Jiang, Pengyao, Park, Soo-Young, Tamarina, Natalia A., Selleck, Scott B., Wittkopp, Patricia J., Bell, Graeme I., Kreitman, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2014
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914626/ https://www.ncbi.nlm.nih.gov/pubmed/24281155 http://dx.doi.org/10.1534/genetics.113.157800

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