Repeated H(2)O(2) exposure drives cell cycle progression in an in vitro model of ulcerative colitis

The production of hydrogen peroxide (H(2)O(2)) drives tumourigenesis in ulcerative colitis (UC). Recently, we showed that H(2)O(2) activates DNA damage checkpoints in human colonic epithelial cells (HCEC) through c-Jun N-terminal Kinases (JNK) that induces p21(WAF1). Moreover, caspases circumvented...

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Detalles Bibliográficos
Autores principales: Poehlmann, Angela, Reissig, Kathrin, Schönfeld, Peter, Walluscheck, Diana, Schinlauer, Antje, Hartig, Roland, Lessel, Wiebke, Guenther, Thomas, Silver, Andrew, Roessner, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914643/
https://www.ncbi.nlm.nih.gov/pubmed/24118792
http://dx.doi.org/10.1111/jcmm.12150

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