The Na(+)/Ca(2+) exchange inhibitor SEA0400 limits intracellular Ca(2+) accumulation and improves recovery of ventricular function when added to cardioplegia

BACKGROUND: The Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents myocardial injury in models of global ischemia and reperfusion. We therefore evaluated its potential as a cardioplegia additive. METHODS: Isolated rat cardiomyocytes were exposed to hypoxia (45 min) followed by reperfusion. During hypo...

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Detalles Bibliográficos
Autores principales: Egar, Jeanne, Ali, Ahmad, Howlett, Susan E, Friesen, Camille Hancock, O’Blenes, Stacy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914709/
https://www.ncbi.nlm.nih.gov/pubmed/24401610
http://dx.doi.org/10.1186/1749-8090-9-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914709/
https://www.ncbi.nlm.nih.gov/pubmed/24401610
http://dx.doi.org/10.1186/1749-8090-9-11

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