Nonclassically Secreted Regulators of Angiogenesis

Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or...

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Detalles Bibliográficos
Autor principal: Prudovsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914728/
https://www.ncbi.nlm.nih.gov/pubmed/24511556
http://dx.doi.org/10.4172/2329-9495.1000101
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author Prudovsky, Igor
author_facet Prudovsky, Igor
author_sort Prudovsky, Igor
collection PubMed
description Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or inflammation in damaged tissues. We review the secreted signal peptide-less regulators of angiogenesis and discuss the mechanisms and biological significance of their unconventional export.
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spelling pubmed-39147282014-02-05 Nonclassically Secreted Regulators of Angiogenesis Prudovsky, Igor Angiol Open Access Article Many secreted polypeptide regulators of angiogenesis are devoid of signal peptides. These proteins are released through nonclassical pathways independent of endoplasmic reticulum and Golgi. In most cases, the nonclassical protein export is induced by stress. It usually serves to stimulate repair or inflammation in damaged tissues. We review the secreted signal peptide-less regulators of angiogenesis and discuss the mechanisms and biological significance of their unconventional export. 2013-02-28 /pmc/articles/PMC3914728/ /pubmed/24511556 http://dx.doi.org/10.4172/2329-9495.1000101 Text en Copyright: © 2013 Prudovsky I. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Prudovsky, Igor
Nonclassically Secreted Regulators of Angiogenesis
title Nonclassically Secreted Regulators of Angiogenesis
title_full Nonclassically Secreted Regulators of Angiogenesis
title_fullStr Nonclassically Secreted Regulators of Angiogenesis
title_full_unstemmed Nonclassically Secreted Regulators of Angiogenesis
title_short Nonclassically Secreted Regulators of Angiogenesis
title_sort nonclassically secreted regulators of angiogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914728/
https://www.ncbi.nlm.nih.gov/pubmed/24511556
http://dx.doi.org/10.4172/2329-9495.1000101
work_keys_str_mv AT prudovskyigor nonclassicallysecretedregulatorsofangiogenesis

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