A Double-edged Sword: Uric Acid and Neurological Disorders

Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons beca...

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Detalles Bibliográficos
Autores principales: Fang, Pu, Li, Xinyuan, Luo, Jin Jun, Wang, Hong, Yang, Xiao-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914730/
https://www.ncbi.nlm.nih.gov/pubmed/24511458
http://dx.doi.org/10.4172/2168-975X.1000109
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author Fang, Pu
Li, Xinyuan
Luo, Jin Jun
Wang, Hong
Yang, Xiao-feng
author_facet Fang, Pu
Li, Xinyuan
Luo, Jin Jun
Wang, Hong
Yang, Xiao-feng
author_sort Fang, Pu
collection PubMed
description Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons because of its induction it impairs antioxidant capacity in the cell. High levels of UA, on the other hand, lead to an inflammatory response contributing to gout or neuroprotection. In this review, we summarize this biphasic function of uric acid and highlight potential therapeutic targets to treat UA-related neurological diseases.
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spelling pubmed-39147302014-02-05 A Double-edged Sword: Uric Acid and Neurological Disorders Fang, Pu Li, Xinyuan Luo, Jin Jun Wang, Hong Yang, Xiao-feng Brain Disord Ther Article Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons because of its induction it impairs antioxidant capacity in the cell. High levels of UA, on the other hand, lead to an inflammatory response contributing to gout or neuroprotection. In this review, we summarize this biphasic function of uric acid and highlight potential therapeutic targets to treat UA-related neurological diseases. 2013-11-01 /pmc/articles/PMC3914730/ /pubmed/24511458 http://dx.doi.org/10.4172/2168-975X.1000109 Text en Copyright: © 2013 Fang P, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Fang, Pu
Li, Xinyuan
Luo, Jin Jun
Wang, Hong
Yang, Xiao-feng
A Double-edged Sword: Uric Acid and Neurological Disorders
title A Double-edged Sword: Uric Acid and Neurological Disorders
title_full A Double-edged Sword: Uric Acid and Neurological Disorders
title_fullStr A Double-edged Sword: Uric Acid and Neurological Disorders
title_full_unstemmed A Double-edged Sword: Uric Acid and Neurological Disorders
title_short A Double-edged Sword: Uric Acid and Neurological Disorders
title_sort double-edged sword: uric acid and neurological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914730/
https://www.ncbi.nlm.nih.gov/pubmed/24511458
http://dx.doi.org/10.4172/2168-975X.1000109
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