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Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging
Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in yo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914823/ https://www.ncbi.nlm.nih.gov/pubmed/24505289 http://dx.doi.org/10.1371/journal.pone.0087421 |
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author | Sauvant, Julie Delpech, Jean-Christophe Palin, Karine De Mota, Nadia Dudit, Jennifer Aubert, Agnès Orcel, Hélène Roux, Pascale Layé, Sophie Moos, Françoise Llorens-Cortes, Catherine Nadjar, Agnès |
author_facet | Sauvant, Julie Delpech, Jean-Christophe Palin, Karine De Mota, Nadia Dudit, Jennifer Aubert, Agnès Orcel, Hélène Roux, Pascale Layé, Sophie Moos, Françoise Llorens-Cortes, Catherine Nadjar, Agnès |
author_sort | Sauvant, Julie |
collection | PubMed |
description | Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. The overactivity of vasopressin neurons was sustained partly by the increased expression of Transient receptor potential vanilloid2 (Trpv2), because central Trpv blocker injection reversed the age-induced increase in plasma vasopressin concentration without modifying plasma apelin concentration. The morphofunctional plasticity of the supraoptic nucleus neuron-astrocyte network normally observed during chronic dehydration in adults appeared to be impaired in aged rats as well. IL-6 overproduction by astrocytes and low-grade microglial neuroinflammation may contribute to the modification of neuronal functioning during aging. Indeed, central treatment with antibodies against IL-6 decreased plasma vasopressin levels and increased plasma apelin concentration toward the values observed in younger adults. Conversely, minocycline treatment (inhibiting microglial metabolism) did not affect plasma vasopressin concentration, but increased plasma apelin concentration toward control values for younger adults. This study is the first to demonstrate dual vasopressin/apelin adaptation mediated by inflammatory molecules and neuronal Trpv2, during aging. |
format | Online Article Text |
id | pubmed-3914823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39148232014-02-06 Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging Sauvant, Julie Delpech, Jean-Christophe Palin, Karine De Mota, Nadia Dudit, Jennifer Aubert, Agnès Orcel, Hélène Roux, Pascale Layé, Sophie Moos, Françoise Llorens-Cortes, Catherine Nadjar, Agnès PLoS One Research Article Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. The overactivity of vasopressin neurons was sustained partly by the increased expression of Transient receptor potential vanilloid2 (Trpv2), because central Trpv blocker injection reversed the age-induced increase in plasma vasopressin concentration without modifying plasma apelin concentration. The morphofunctional plasticity of the supraoptic nucleus neuron-astrocyte network normally observed during chronic dehydration in adults appeared to be impaired in aged rats as well. IL-6 overproduction by astrocytes and low-grade microglial neuroinflammation may contribute to the modification of neuronal functioning during aging. Indeed, central treatment with antibodies against IL-6 decreased plasma vasopressin levels and increased plasma apelin concentration toward the values observed in younger adults. Conversely, minocycline treatment (inhibiting microglial metabolism) did not affect plasma vasopressin concentration, but increased plasma apelin concentration toward control values for younger adults. This study is the first to demonstrate dual vasopressin/apelin adaptation mediated by inflammatory molecules and neuronal Trpv2, during aging. Public Library of Science 2014-02-05 /pmc/articles/PMC3914823/ /pubmed/24505289 http://dx.doi.org/10.1371/journal.pone.0087421 Text en © 2014 Sauvant et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sauvant, Julie Delpech, Jean-Christophe Palin, Karine De Mota, Nadia Dudit, Jennifer Aubert, Agnès Orcel, Hélène Roux, Pascale Layé, Sophie Moos, Françoise Llorens-Cortes, Catherine Nadjar, Agnès Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title | Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title_full | Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title_fullStr | Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title_full_unstemmed | Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title_short | Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging |
title_sort | mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914823/ https://www.ncbi.nlm.nih.gov/pubmed/24505289 http://dx.doi.org/10.1371/journal.pone.0087421 |
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