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Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China
BACKGROUND: Norovirus (NoV) has been recognized as the most important cause of nonbacterial acute gastroenteritis affecting all age group people in the world. Genetic recombination is a common occurance in RNA viruses and many recombinant NoV strains have been described since it was first reported i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914918/ https://www.ncbi.nlm.nih.gov/pubmed/24505432 http://dx.doi.org/10.1371/journal.pone.0088210 |
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author | Sang, Shaowei Zhao, Zhongtang Suo, Jijiang Xing, Yubin Jia, Ning Gao, Yan Xie, Lijun Du, Mingmei Liu, Bowei Ren, Shiwang Liu, Yunxi |
author_facet | Sang, Shaowei Zhao, Zhongtang Suo, Jijiang Xing, Yubin Jia, Ning Gao, Yan Xie, Lijun Du, Mingmei Liu, Bowei Ren, Shiwang Liu, Yunxi |
author_sort | Sang, Shaowei |
collection | PubMed |
description | BACKGROUND: Norovirus (NoV) has been recognized as the most important cause of nonbacterial acute gastroenteritis affecting all age group people in the world. Genetic recombination is a common occurance in RNA viruses and many recombinant NoV strains have been described since it was first reported in 1997. However, the knowledge of recombinant NoV in China is extremely limited. METHODS: A total of 685 stool specimens were tested for NoV infection from the acute gastroenteritis patients who visited one general hospital in Beijing from April 2009 to November 2011. The virus recombination was identified by constructing phylogenetic trees of two genes, further SimPlot and the maximum chi-square analysis. RESULTS: The overall positive rate was 9.6% (66/685). GII.4 New Orleans 2009 and GII.4 2006b variants were the dominant genotype. Four GII.g/GII.12 and one GII.12/GII.3 recombinant strains were confirmed, and all derived from adult outpatients. The predictive recombination point occurred at the open reading frame (ORF)1/ORF2 overlap. CONCLUSIONS: The GII.g ORF1/GII.12ORF2 recombinant has been reported in several countries and it was the first report of this recombinant in China. |
format | Online Article Text |
id | pubmed-3914918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39149182014-02-06 Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China Sang, Shaowei Zhao, Zhongtang Suo, Jijiang Xing, Yubin Jia, Ning Gao, Yan Xie, Lijun Du, Mingmei Liu, Bowei Ren, Shiwang Liu, Yunxi PLoS One Research Article BACKGROUND: Norovirus (NoV) has been recognized as the most important cause of nonbacterial acute gastroenteritis affecting all age group people in the world. Genetic recombination is a common occurance in RNA viruses and many recombinant NoV strains have been described since it was first reported in 1997. However, the knowledge of recombinant NoV in China is extremely limited. METHODS: A total of 685 stool specimens were tested for NoV infection from the acute gastroenteritis patients who visited one general hospital in Beijing from April 2009 to November 2011. The virus recombination was identified by constructing phylogenetic trees of two genes, further SimPlot and the maximum chi-square analysis. RESULTS: The overall positive rate was 9.6% (66/685). GII.4 New Orleans 2009 and GII.4 2006b variants were the dominant genotype. Four GII.g/GII.12 and one GII.12/GII.3 recombinant strains were confirmed, and all derived from adult outpatients. The predictive recombination point occurred at the open reading frame (ORF)1/ORF2 overlap. CONCLUSIONS: The GII.g ORF1/GII.12ORF2 recombinant has been reported in several countries and it was the first report of this recombinant in China. Public Library of Science 2014-02-05 /pmc/articles/PMC3914918/ /pubmed/24505432 http://dx.doi.org/10.1371/journal.pone.0088210 Text en © 2014 Sang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sang, Shaowei Zhao, Zhongtang Suo, Jijiang Xing, Yubin Jia, Ning Gao, Yan Xie, Lijun Du, Mingmei Liu, Bowei Ren, Shiwang Liu, Yunxi Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title | Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title_full | Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title_fullStr | Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title_full_unstemmed | Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title_short | Report of Recombinant Norovirus GII.g/GII.12 in Beijing, China |
title_sort | report of recombinant norovirus gii.g/gii.12 in beijing, china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914918/ https://www.ncbi.nlm.nih.gov/pubmed/24505432 http://dx.doi.org/10.1371/journal.pone.0088210 |
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