Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex

The small GTPase cycles between the inactive GDP form and the activated GTP form, catalyzed by the upstream guanine exchange factors. The modulation of such process by small molecules has been proven to be a fruitful route for therapeutic intervention to prevent the over-activation of the small GTPa...

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Detalles Bibliográficos
Autores principales: Gao, Jia, Ma, Rongsheng, Wang, Wei, Wang, Na, Sasaki, Ryan, Snyderman, David, Wu, Jihui, Ruan, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914932/
https://www.ncbi.nlm.nih.gov/pubmed/24505392
http://dx.doi.org/10.1371/journal.pone.0088098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914932/
https://www.ncbi.nlm.nih.gov/pubmed/24505392
http://dx.doi.org/10.1371/journal.pone.0088098

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