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Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations
Lung cancer is one of the leading causes of cancer mortality worldwide and non–small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914971/ https://www.ncbi.nlm.nih.gov/pubmed/24505469 http://dx.doi.org/10.1371/journal.pone.0088300 |
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author | Li, Bi-Qing You, Jin Huang, Tao Cai, Yu-Dong |
author_facet | Li, Bi-Qing You, Jin Huang, Tao Cai, Yu-Dong |
author_sort | Li, Bi-Qing |
collection | PubMed |
description | Lung cancer is one of the leading causes of cancer mortality worldwide and non–small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In this study, we compared the genome-wide copy number alterations (CNAs) patterns of 208 early stage ACA and 93 early stage SCC tumor samples. As a result, 266 CNA probes stood out for better discrimination of ACA and SCC. It was revealed that the genes corresponding to these 266 probes were enriched in lung cancer related pathways and enriched in the chromosome regions where CNA usually occur in lung cancer. This study sheds lights on the CNA study of NSCLC and provides some insights on the epigenetic of NSCLC. |
format | Online Article Text |
id | pubmed-3914971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39149712014-02-06 Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations Li, Bi-Qing You, Jin Huang, Tao Cai, Yu-Dong PLoS One Research Article Lung cancer is one of the leading causes of cancer mortality worldwide and non–small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In this study, we compared the genome-wide copy number alterations (CNAs) patterns of 208 early stage ACA and 93 early stage SCC tumor samples. As a result, 266 CNA probes stood out for better discrimination of ACA and SCC. It was revealed that the genes corresponding to these 266 probes were enriched in lung cancer related pathways and enriched in the chromosome regions where CNA usually occur in lung cancer. This study sheds lights on the CNA study of NSCLC and provides some insights on the epigenetic of NSCLC. Public Library of Science 2014-02-05 /pmc/articles/PMC3914971/ /pubmed/24505469 http://dx.doi.org/10.1371/journal.pone.0088300 Text en © 2014 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Bi-Qing You, Jin Huang, Tao Cai, Yu-Dong Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title | Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title_full | Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title_fullStr | Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title_full_unstemmed | Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title_short | Classification of Non-Small Cell Lung Cancer Based on Copy Number Alterations |
title_sort | classification of non-small cell lung cancer based on copy number alterations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914971/ https://www.ncbi.nlm.nih.gov/pubmed/24505469 http://dx.doi.org/10.1371/journal.pone.0088300 |
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