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CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

Current combined surgical and neo-adjuvant chemotherapy of primary metastatic osteosarcoma (OS) is ineffective, reflected by a 5-year survival rate of affected patients of less than 20 %. Studies in experimental OS metastasis models pointed to the CXCR4/CXCL12 homing axis as a novel target for OS me...

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Detalles Bibliográficos
Autores principales:	Brennecke, Patrick, Arlt, Matthias J. E., Campanile, Carmen, Husmann, Knut, Gvozdenovic, Ana, Apuzzo, Tiziana, Thelen, Marcus, Born, Walter, Fuchs, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915086/ https://www.ncbi.nlm.nih.gov/pubmed/24390633 http://dx.doi.org/10.1007/s10585-013-9632-3

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