Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer

BACKGROUND: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. METHODS: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55–69 years. At...

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Autores principales: Deckers, I A G, van den Brandt, P A, van Engeland, M, Soetekouw, P M M B, Baldewijns, M M L L, Goldbohm, R A, Schouten, L J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915132/
https://www.ncbi.nlm.nih.gov/pubmed/24327014
http://dx.doi.org/10.1038/bjc.2013.771
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author Deckers, I A G
van den Brandt, P A
van Engeland, M
Soetekouw, P M M B
Baldewijns, M M L L
Goldbohm, R A
Schouten, L J
author_facet Deckers, I A G
van den Brandt, P A
van Engeland, M
Soetekouw, P M M B
Baldewijns, M M L L
Goldbohm, R A
Schouten, L J
author_sort Deckers, I A G
collection PubMed
description BACKGROUND: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. METHODS: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55–69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. RESULTS: Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02). CONCLUSION: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.
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spelling pubmed-39151322015-02-04 Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer Deckers, I A G van den Brandt, P A van Engeland, M Soetekouw, P M M B Baldewijns, M M L L Goldbohm, R A Schouten, L J Br J Cancer Epidemiology BACKGROUND: As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC. METHODS: The Netherlands Cohort Study (NLCS) with case-cohort design included 120 852 participants aged 55–69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses. RESULTS: Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02). CONCLUSION: Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low. Nature Publishing Group 2014-02-04 2013-12-10 /pmc/articles/PMC3915132/ /pubmed/24327014 http://dx.doi.org/10.1038/bjc.2013.771 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Deckers, I A G
van den Brandt, P A
van Engeland, M
Soetekouw, P M M B
Baldewijns, M M L L
Goldbohm, R A
Schouten, L J
Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title_full Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title_fullStr Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title_full_unstemmed Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title_short Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer
title_sort long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the netherlands cohort study on diet and cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915132/
https://www.ncbi.nlm.nih.gov/pubmed/24327014
http://dx.doi.org/10.1038/bjc.2013.771
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