A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immun...

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Detalles Bibliográficos
Autores principales: Ushio, Hiroyuki, Ishibuchi, Seigo, Oshita, Koichi, Seki, Noriyasu, Kataoka, Hirotoshi, Sugahara, Kunio, Adachi, Kunitomo, Chiba, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915191/
https://www.ncbi.nlm.nih.gov/pubmed/24366113
http://dx.doi.org/10.3390/ph7010001

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