T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers

T cell acute lymphoblastic leukemia (ALL) is an invasive disease with a higher incidence in children and adolescents. In terms of Immunophenotype, T-ALL is positive for CD2, CD7, CD34 and HLA-DR, and the level of these markers is increased with increasing age. In addition, the myeloid markers (CD13,...

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Autores principales: Ahmadzadeh, Ahmad, Saedi, Sajedeh, Jaseb, Kaveh, Asnafi, Ali Amin, Alghasi, Arash, Saki, Najmaldin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915421/
https://www.ncbi.nlm.nih.gov/pubmed/24505542
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author Ahmadzadeh, Ahmad
Saedi, Sajedeh
Jaseb, Kaveh
Asnafi, Ali Amin
Alghasi, Arash
Saki, Najmaldin
author_facet Ahmadzadeh, Ahmad
Saedi, Sajedeh
Jaseb, Kaveh
Asnafi, Ali Amin
Alghasi, Arash
Saki, Najmaldin
author_sort Ahmadzadeh, Ahmad
collection PubMed
description T cell acute lymphoblastic leukemia (ALL) is an invasive disease with a higher incidence in children and adolescents. In terms of Immunophenotype, T-ALL is positive for CD2, CD7, CD34 and HLA-DR, and the level of these markers is increased with increasing age. In addition, the myeloid markers (CD13, CD33) are sometimes expressed in T-ALL. In this study, we introduce a rare case of a 28-year-old woman with T-ALL with aberrant expression of myeloid markers (CD13), without lymphadenopathy and with 94% blasts in bone marrow specimens. The patient has the rare karyotype of 46,XX del(7)(q11.2q22). The presence of del7 is a rare phenomenon in T-ALL.
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spelling pubmed-39154212014-02-06 T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers Ahmadzadeh, Ahmad Saedi, Sajedeh Jaseb, Kaveh Asnafi, Ali Amin Alghasi, Arash Saki, Najmaldin Int J Hematol Oncol Stem Cell Res Case Report T cell acute lymphoblastic leukemia (ALL) is an invasive disease with a higher incidence in children and adolescents. In terms of Immunophenotype, T-ALL is positive for CD2, CD7, CD34 and HLA-DR, and the level of these markers is increased with increasing age. In addition, the myeloid markers (CD13, CD33) are sometimes expressed in T-ALL. In this study, we introduce a rare case of a 28-year-old woman with T-ALL with aberrant expression of myeloid markers (CD13), without lymphadenopathy and with 94% blasts in bone marrow specimens. The patient has the rare karyotype of 46,XX del(7)(q11.2q22). The presence of del7 is a rare phenomenon in T-ALL. Tehran University of Medical Sciences 2013 /pmc/articles/PMC3915421/ /pubmed/24505542 Text en © 2013 Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Case Report
Ahmadzadeh, Ahmad
Saedi, Sajedeh
Jaseb, Kaveh
Asnafi, Ali Amin
Alghasi, Arash
Saki, Najmaldin
T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title_full T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title_fullStr T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title_full_unstemmed T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title_short T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers
title_sort t-cell acute lymphoblastic leukemia with del (7) (q11.2q22) and aberrant expression of myeloid markers
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915421/
https://www.ncbi.nlm.nih.gov/pubmed/24505542
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