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The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients

BACKGROUND: β−Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the pres...

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Autores principales: Hashemian, Z, Hashemi, A, Fateminasab, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Sadoughi University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915432/
https://www.ncbi.nlm.nih.gov/pubmed/24575256
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author Hashemian, Z
Hashemi, A
Fateminasab, M
author_facet Hashemian, Z
Hashemi, A
Fateminasab, M
author_sort Hashemian, Z
collection PubMed
description BACKGROUND: β−Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the present study was to determine the benefits of vitamin E as an antioxidant supplements in β-Thalassemia children. MATERIALS AND METHODS: This clinical trial was carried out on 45 beta-thalassemic patients undergoing occasional transfusions (24 males, 21 females), mean age 16± 8 years, admitted to Yazd and Shahid Sadoughi hospital in 2011. Fallowing three months treatment of vitaminE (vitamin E 400-600 unit/day),liver function test and hemopoitic system parameters were measured. RESULTS: Fourty five patients with laboratory confirmation of β-Thalassemia were recruited following three months vitamin E supplementation, liver function test had higher improvement compared to hemopoitic system parameters , and also serum SGOT was significantly reduced (P-value<0.004 ). CONCLUSION: It seems clear that treatments of β-thalassemic patients with vitamins E have benefits in promoting antioxidant status and may improve liver function test, as AST and ALT to decrease but this supplement is not effective for hemopoietic system variables.
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spelling pubmed-39154322014-02-26 The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients Hashemian, Z Hashemi, A Fateminasab, M Iran J Ped Hematol Oncol Original Article BACKGROUND: β−Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the present study was to determine the benefits of vitamin E as an antioxidant supplements in β-Thalassemia children. MATERIALS AND METHODS: This clinical trial was carried out on 45 beta-thalassemic patients undergoing occasional transfusions (24 males, 21 females), mean age 16± 8 years, admitted to Yazd and Shahid Sadoughi hospital in 2011. Fallowing three months treatment of vitaminE (vitamin E 400-600 unit/day),liver function test and hemopoitic system parameters were measured. RESULTS: Fourty five patients with laboratory confirmation of β-Thalassemia were recruited following three months vitamin E supplementation, liver function test had higher improvement compared to hemopoitic system parameters , and also serum SGOT was significantly reduced (P-value<0.004 ). CONCLUSION: It seems clear that treatments of β-thalassemic patients with vitamins E have benefits in promoting antioxidant status and may improve liver function test, as AST and ALT to decrease but this supplement is not effective for hemopoietic system variables. Shahid Sadoughi University of Medical Sciences 2012 2012-09-22 /pmc/articles/PMC3915432/ /pubmed/24575256 Text en © 2012: Iranian Journal of Pediatric Hematology Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Hashemian, Z
Hashemi, A
Fateminasab, M
The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title_full The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title_fullStr The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title_full_unstemmed The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title_short The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients
title_sort benefits of vitamin e on liver function and the hemopoietic system in thalassemia patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915432/
https://www.ncbi.nlm.nih.gov/pubmed/24575256
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