Cargando…

The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?

Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not un...

Descripción completa

Detalles Bibliográficos
Autores principales: Kvist, Torben Madsen, Schwarz, Peter, Jørgensen, Niklas Rye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915485/
https://www.ncbi.nlm.nih.gov/pubmed/24574936
http://dx.doi.org/10.1155/2014/954530
_version_ 1782302593498742784
author Kvist, Torben Madsen
Schwarz, Peter
Jørgensen, Niklas Rye
author_facet Kvist, Torben Madsen
Schwarz, Peter
Jørgensen, Niklas Rye
author_sort Kvist, Torben Madsen
collection PubMed
description Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis.
format Online
Article
Text
id pubmed-3915485
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39154852014-02-26 The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? Kvist, Torben Madsen Schwarz, Peter Jørgensen, Niklas Rye ScientificWorldJournal Review Article Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis. Hindawi Publishing Corporation 2014-01-16 /pmc/articles/PMC3915485/ /pubmed/24574936 http://dx.doi.org/10.1155/2014/954530 Text en Copyright © 2014 Torben Madsen Kvist et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kvist, Torben Madsen
Schwarz, Peter
Jørgensen, Niklas Rye
The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title_full The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title_fullStr The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title_full_unstemmed The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title_short The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
title_sort p2x7 receptor: a key player in immune-mediated bone loss?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915485/
https://www.ncbi.nlm.nih.gov/pubmed/24574936
http://dx.doi.org/10.1155/2014/954530
work_keys_str_mv AT kvisttorbenmadsen thep2x7receptorakeyplayerinimmunemediatedboneloss
AT schwarzpeter thep2x7receptorakeyplayerinimmunemediatedboneloss
AT jørgensenniklasrye thep2x7receptorakeyplayerinimmunemediatedboneloss
AT kvisttorbenmadsen p2x7receptorakeyplayerinimmunemediatedboneloss
AT schwarzpeter p2x7receptorakeyplayerinimmunemediatedboneloss
AT jørgensenniklasrye p2x7receptorakeyplayerinimmunemediatedboneloss