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The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not un...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915485/ https://www.ncbi.nlm.nih.gov/pubmed/24574936 http://dx.doi.org/10.1155/2014/954530 |
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author | Kvist, Torben Madsen Schwarz, Peter Jørgensen, Niklas Rye |
author_facet | Kvist, Torben Madsen Schwarz, Peter Jørgensen, Niklas Rye |
author_sort | Kvist, Torben Madsen |
collection | PubMed |
description | Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis. |
format | Online Article Text |
id | pubmed-3915485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39154852014-02-26 The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? Kvist, Torben Madsen Schwarz, Peter Jørgensen, Niklas Rye ScientificWorldJournal Review Article Inflammatory diseases are often multiorganic diseases with manifestations not related directly to the primary affected organ. They are often complicated by a generalized bone loss that subsequently leads to osteoporosis and bone fractures. The exact mechanism for the accompanying bone loss is not understood in full detail, but factors such as glucocorticoid treatment, immobilization, malnutrition, and insufficient intake of vitamin D play a role. However, it has become evident that the inflammatory process itself is involved and the resulting bone loss is termed immune-mediated bone loss. It stems from an increase in bone resorption and the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1 beta and has been shown to not only mediate the inflammatory response but also to strongly stimulate bone degradation. The purinergic P2X7 receptor is central in the processing of these two cytokines and in the initiation of the inflammatory response, and it is a key molecule in the regulation of both bone formation and bone resorption. The aim of this review is therefore to provide evidence-based novel hypotheses of the role of ATP-mediated purinergic signalling via the P2X7 receptor in immune-mediated bone loss and -osteoporosis. Hindawi Publishing Corporation 2014-01-16 /pmc/articles/PMC3915485/ /pubmed/24574936 http://dx.doi.org/10.1155/2014/954530 Text en Copyright © 2014 Torben Madsen Kvist et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kvist, Torben Madsen Schwarz, Peter Jørgensen, Niklas Rye The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title | The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title_full | The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title_fullStr | The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title_full_unstemmed | The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title_short | The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss? |
title_sort | p2x7 receptor: a key player in immune-mediated bone loss? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915485/ https://www.ncbi.nlm.nih.gov/pubmed/24574936 http://dx.doi.org/10.1155/2014/954530 |
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