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Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?

Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiog...

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Autores principales: Vafaeimanesh, Jamshid, Hejazi, Seyyed Fakhroldin, Damanpak, Vahid, Vahedian, Mostafa, Sattari, Mohammadamin, Seyyedmajidi, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915494/
https://www.ncbi.nlm.nih.gov/pubmed/24574896
http://dx.doi.org/10.1155/2014/516354
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author Vafaeimanesh, Jamshid
Hejazi, Seyyed Fakhroldin
Damanpak, Vahid
Vahedian, Mostafa
Sattari, Mohammadamin
Seyyedmajidi, Mohammadreza
author_facet Vafaeimanesh, Jamshid
Hejazi, Seyyed Fakhroldin
Damanpak, Vahid
Vahedian, Mostafa
Sattari, Mohammadamin
Seyyedmajidi, Mohammadreza
author_sort Vafaeimanesh, Jamshid
collection PubMed
description Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P = 0.006). Positive CAD was significantly associated with HDL level (P = 0.01) and ESR level (P = 0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P < 0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD.
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spelling pubmed-39154942014-02-26 Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor? Vafaeimanesh, Jamshid Hejazi, Seyyed Fakhroldin Damanpak, Vahid Vahedian, Mostafa Sattari, Mohammadamin Seyyedmajidi, Mohammadreza ScientificWorldJournal Research Article Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P = 0.006). Positive CAD was significantly associated with HDL level (P = 0.01) and ESR level (P = 0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P < 0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD. Hindawi Publishing Corporation 2014-01-16 /pmc/articles/PMC3915494/ /pubmed/24574896 http://dx.doi.org/10.1155/2014/516354 Text en Copyright © 2014 Jamshid Vafaeimanesh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vafaeimanesh, Jamshid
Hejazi, Seyyed Fakhroldin
Damanpak, Vahid
Vahedian, Mostafa
Sattari, Mohammadamin
Seyyedmajidi, Mohammadreza
Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title_full Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title_fullStr Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title_full_unstemmed Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title_short Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?
title_sort association of helicobacter pylori infection with coronary artery disease: is helicobacter pylori a risk factor?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915494/
https://www.ncbi.nlm.nih.gov/pubmed/24574896
http://dx.doi.org/10.1155/2014/516354
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