Kinetic Evidence for Near Irreversible Nonionic Micellar Entrapment of N-(2′-Methoxyphenyl)phthalimide (1) under the Typical Alkaline Reaction Conditions

The values of pseudo-first-order rate constants (k (obs)) for alkaline hydrolysis of 1, obtained at 1.0 mM NaOH and within [ C(m)E(n)T] (total concentration of C(m)E(n)) range of 3.0–5.0 mM for C(12)E(23) and 10–20 mM for C(18)E(20), fail to obey pseudophase micellar (PM) model. The values of the fraction of near irreversible C(m)E(n) micellar trapped 1 molecules (F (IT1)) vary in the range ~0–0.75 for C(12)E(23) and ~0–0.83 for C(18)E(20) under such conditions. The values of F (IT1) become 1.0 at ≥10 mM C(12)E(23) and 50 mM C(18)E(20). Kinetic analysis of the observed data at ≥10 mM C(12)E(23) shows near irreversible micellar entrapment of 1 molecules under such conditions.