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Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients
Personalized medicine has become essential in the treatment of lung cancer. However, the lung cancer-related gene expression profiles in non-small cell lung cancer (NSCLC) patients have not been elucidated. In this study, the correlation between gene expression profiles and clinicopathological chara...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915665/ https://www.ncbi.nlm.nih.gov/pubmed/24649266 http://dx.doi.org/10.3892/mco.2013.153 |
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author | HAN, YI LI, GUO SU, CHONGYU REN, HUA CHU, XIANGYANG ZHAO, QIUYUE ZHU, YANJUN WANG, ZITONG HU, BIN AN, GUANGYU KANG, JINGBO WANG, WEI YU, DAPING SONG, XIAOYUN XIAO, NING LI, YUNSONG LI, XIA YANG, HUIYI YU, GANG LIU, ZHIDONG |
author_facet | HAN, YI LI, GUO SU, CHONGYU REN, HUA CHU, XIANGYANG ZHAO, QIUYUE ZHU, YANJUN WANG, ZITONG HU, BIN AN, GUANGYU KANG, JINGBO WANG, WEI YU, DAPING SONG, XIAOYUN XIAO, NING LI, YUNSONG LI, XIA YANG, HUIYI YU, GANG LIU, ZHIDONG |
author_sort | HAN, YI |
collection | PubMed |
description | Personalized medicine has become essential in the treatment of lung cancer. However, the lung cancer-related gene expression profiles in non-small cell lung cancer (NSCLC) patients have not been elucidated. In this study, the correlation between gene expression profiles and clinicopathological characteristics was investigated in NSCLC patients. A total of 95 patients were enrolled in this study. The mRNA expression levels of 14 genes were assessed by multiplex branched DNA liquidchip (MBL) technology and data on 9 clinicopathological characteristics of patients were collected simultaneously. The correlation between gene expression and clinicopathological characteristics was investigated. Out of the 9 clinicopathological parameters, 6 were associated with several of the 14 genes analyzed. Patient gender was associated with TYMS and TOP2A. Clinical stage was associated with VEGFR2, KIT and HER2. There was weak correlation between primary tumor size of ≤3 cm and the expression level of KIT. The mRNA expression levels of VEGFR2 and HER2 correlated with distant metastasis. BRCA1, TYMS, TOP2A and HER2 were associated with histological type. Smoking correlated with higher expression levels of BRCA1, TYMS and TOP2A and lower expression levels of PDGFRβ. The results were suggestive of correlation between the clinicopathological parameters of the NSCLC patients and the mRNA expression levels of certain lung cancer-related genes, including BRCA1, TYMS, TOP2A, PDGFRβ, VEGFR2, KIT and HER2. |
format | Online Article Text |
id | pubmed-3915665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-39156652014-03-19 Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients HAN, YI LI, GUO SU, CHONGYU REN, HUA CHU, XIANGYANG ZHAO, QIUYUE ZHU, YANJUN WANG, ZITONG HU, BIN AN, GUANGYU KANG, JINGBO WANG, WEI YU, DAPING SONG, XIAOYUN XIAO, NING LI, YUNSONG LI, XIA YANG, HUIYI YU, GANG LIU, ZHIDONG Mol Clin Oncol Articles Personalized medicine has become essential in the treatment of lung cancer. However, the lung cancer-related gene expression profiles in non-small cell lung cancer (NSCLC) patients have not been elucidated. In this study, the correlation between gene expression profiles and clinicopathological characteristics was investigated in NSCLC patients. A total of 95 patients were enrolled in this study. The mRNA expression levels of 14 genes were assessed by multiplex branched DNA liquidchip (MBL) technology and data on 9 clinicopathological characteristics of patients were collected simultaneously. The correlation between gene expression and clinicopathological characteristics was investigated. Out of the 9 clinicopathological parameters, 6 were associated with several of the 14 genes analyzed. Patient gender was associated with TYMS and TOP2A. Clinical stage was associated with VEGFR2, KIT and HER2. There was weak correlation between primary tumor size of ≤3 cm and the expression level of KIT. The mRNA expression levels of VEGFR2 and HER2 correlated with distant metastasis. BRCA1, TYMS, TOP2A and HER2 were associated with histological type. Smoking correlated with higher expression levels of BRCA1, TYMS and TOP2A and lower expression levels of PDGFRβ. The results were suggestive of correlation between the clinicopathological parameters of the NSCLC patients and the mRNA expression levels of certain lung cancer-related genes, including BRCA1, TYMS, TOP2A, PDGFRβ, VEGFR2, KIT and HER2. D.A. Spandidos 2013-09 2013-07-23 /pmc/articles/PMC3915665/ /pubmed/24649266 http://dx.doi.org/10.3892/mco.2013.153 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles HAN, YI LI, GUO SU, CHONGYU REN, HUA CHU, XIANGYANG ZHAO, QIUYUE ZHU, YANJUN WANG, ZITONG HU, BIN AN, GUANGYU KANG, JINGBO WANG, WEI YU, DAPING SONG, XIAOYUN XIAO, NING LI, YUNSONG LI, XIA YANG, HUIYI YU, GANG LIU, ZHIDONG Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title | Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title_full | Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title_fullStr | Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title_full_unstemmed | Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title_short | Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients |
title_sort | exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of nsclc patients |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915665/ https://www.ncbi.nlm.nih.gov/pubmed/24649266 http://dx.doi.org/10.3892/mco.2013.153 |
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