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Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients

Gastroesophageal reflux is a common condition in the pediatric population, with an increasing incidence in the last few years. It can be defined as an effortless retrograde movement of gastric contents into the esophagus related to complex multifactorial pathogenesis, involving anatomical, hormonal,...

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Detalles Bibliográficos
Autores principales: Cardile, Sabrina, Romano, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915886/
https://www.ncbi.nlm.nih.gov/pubmed/24600284
http://dx.doi.org/10.2147/AHMT.S23193
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author Cardile, Sabrina
Romano, Claudio
author_facet Cardile, Sabrina
Romano, Claudio
author_sort Cardile, Sabrina
collection PubMed
description Gastroesophageal reflux is a common condition in the pediatric population, with an increasing incidence in the last few years. It can be defined as an effortless retrograde movement of gastric contents into the esophagus related to complex multifactorial pathogenesis, involving anatomical, hormonal, environmental, and genetic factors. In some cases, it may be associated with esophageal or extraesophageal symptoms (heartburn and regurgitation), and is defined as gastroesophageal reflux disease (GERD). The therapeutic approach to gastroesophageal reflux in infants and children is often conservative, including changes in lifestyle (eg, posture and thickening of meals). If these children remain symptomatic after lifestyle changes (nutrition, feeding, and positional modification), or present with clinical red flags (poor weight gain, recurrent respiratory symptoms, or hematemesis) and complications of GERD (esophagitis, bleeding, stricture, Barrett’s esophagus, or adenocarcinoma) it may be necessary to set up a proper diagnostic protocol. Proton pump inhibitors have been recommended as the most effective acid suppression therapy for adults and pediatric patients. Esomeprazole, the S-isomer of omeprazole, is the only single-isomer proton pump inhibitor available. The paper assesses the safety and tolerability of esomeprazole in pediatric and adolescent patients.
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spelling pubmed-39158862014-03-05 Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients Cardile, Sabrina Romano, Claudio Adolesc Health Med Ther Review Gastroesophageal reflux is a common condition in the pediatric population, with an increasing incidence in the last few years. It can be defined as an effortless retrograde movement of gastric contents into the esophagus related to complex multifactorial pathogenesis, involving anatomical, hormonal, environmental, and genetic factors. In some cases, it may be associated with esophageal or extraesophageal symptoms (heartburn and regurgitation), and is defined as gastroesophageal reflux disease (GERD). The therapeutic approach to gastroesophageal reflux in infants and children is often conservative, including changes in lifestyle (eg, posture and thickening of meals). If these children remain symptomatic after lifestyle changes (nutrition, feeding, and positional modification), or present with clinical red flags (poor weight gain, recurrent respiratory symptoms, or hematemesis) and complications of GERD (esophagitis, bleeding, stricture, Barrett’s esophagus, or adenocarcinoma) it may be necessary to set up a proper diagnostic protocol. Proton pump inhibitors have been recommended as the most effective acid suppression therapy for adults and pediatric patients. Esomeprazole, the S-isomer of omeprazole, is the only single-isomer proton pump inhibitor available. The paper assesses the safety and tolerability of esomeprazole in pediatric and adolescent patients. Dove Medical Press 2012-02-28 /pmc/articles/PMC3915886/ /pubmed/24600284 http://dx.doi.org/10.2147/AHMT.S23193 Text en © 2012 Cardile and Romano, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Cardile, Sabrina
Romano, Claudio
Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title_full Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title_fullStr Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title_full_unstemmed Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title_short Clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
title_sort clinical utility of esomeprazole for treatment of gastroesophageal reflux disease in pediatric and adolescent patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915886/
https://www.ncbi.nlm.nih.gov/pubmed/24600284
http://dx.doi.org/10.2147/AHMT.S23193
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